组织培养繁殖的犬瘟热病毒的毒力
Virulence of tissue culture-propagated canine distemper virus.
作者信息
Metzler A E, Higgins R J, Krakowka S, Koestner A
出版信息
Infect Immun. 1980 Sep;29(3):940-4. doi: 10.1128/iai.29.3.940-944.1980.
Abstract
Virulence of canine distemper virus (CDV) adapted to in vitro growth in Vero or bovine cells was determined by inoculation into CDV-susceptible neonatal gnotobiotic dogs. When compared with dogs given virulent R252-CDV, Vero R252-CDV was attenuated at passage level 14. In contrast, dogs inoculated with bovine R252-CDV at the same passage level experienced rapid fatal neurological disease. Virulence was not linked to ability to infect or replicate in canine pulmonary macrophage cultures. Retention of virulence by bovine R252-CDV is unique and worthy of further study.
摘要
通过接种到对犬瘟热病毒（CDV）易感的新生无菌犬中，测定适应于在Vero细胞或牛细胞中进行体外生长的犬瘟热病毒的毒力。与接种强毒株R252-CDV的犬相比，Vero R252-CDV在传代至第14代时毒力减弱。相比之下，接种相同传代水平牛R252-CDV的犬出现了快速致命的神经疾病。毒力与在犬肺巨噬细胞培养物中的感染或复制能力无关。牛R252-CDV毒力的保留是独特的，值得进一步研究。
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