强毒犬瘟热病毒在淋巴母细胞样细胞系中的持续性
Persistence of virulent canine distemper virus in lymphoblastoid cell lines.
作者信息
Friedlander J M, Summers B A, Appel M J
出版信息
Arch Virol. 1985;86(1-2):47-62. doi: 10.1007/BF01314113.
PMID:2994601
Abstract
Persistent infection with virulent canine distemper virus (CDV-SH) was established in 2 human lymphoblastoid B cell lines (Wi-L2 and Raji), and one human (HSB), one simian (1670) and one canine (CT-45-S) lymphoblastoid T cell line. Cell free virus from persistently infected T cell lines was avirulent for dogs but virulence was maintained during 31 cell passages in persistently infected B cell lines.
摘要
在两个人类淋巴母细胞B细胞系（Wi-L2和Raji）以及一个人类（HSB）、一个猿猴（1670）和一个犬类（CT-45-S）淋巴母细胞T细胞系中建立了强毒犬瘟热病毒（CDV-SH）的持续感染。来自持续感染T细胞系的无细胞病毒对犬无毒，但在持续感染的B细胞系中经过31次细胞传代后仍保持毒力。
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