Panijpan B, Ratanaubolchai K
Int J Vitam Nutr Res. 1980;50(3):247-53.
Interactions between thiamine and antithiamine polyphenolic compounds exhibit similar pseudo-first order rate constants and Arrhenius activation energy. Probably, hydroxide ions open the thiazole moiety of thiamine to give a sulphydryl derivative existing in equilibrium with thiamine. Ionization and air oxidation of the polyphenols yield oxidized forms which may be quinones and others. Catalytic and rapid oxidation by the quinones lead to formation of thiamine disulphide from the sulphydryl derivative shifting the equilibrium away from thiamine.
硫胺素与抗硫胺素多酚化合物之间的相互作用表现出相似的准一级速率常数和阿伦尼乌斯活化能。可能是氢氧根离子打开硫胺素的噻唑部分，生成与硫胺素处于平衡状态的巯基衍生物。多酚的电离和空气氧化产生氧化形式，可能是醌类和其他物质。醌类的催化快速氧化导致巯基衍生物形成硫胺素二硫化物，使平衡远离硫胺素。
