镰状细胞贫血患者血浆的致动脉粥样硬化指数

On artherogenic index of plasma in sickle cell anaemia patients.

作者信息

Akinbami Akinsegun Abduljaleel, Uche Ebele Ifeyinwa, Suleiman Aishatu Maude, Ogbenna Ann Abiola, Olowoselu Festus Olusola, Augustine Benjamin, Badiru Mulikat Adesola, Bamiro Rafat Abiodun, Kamson Omolara Risqat

机构信息

Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine PMB 21266, Ikeja, Lagos, Lagos State, Nigeria.

Department of Haematology and Blood Transfusion, Faculty of Basic Clinical Sciences, College of Health Sciences, Ahmadu Bello University, Zaria.

出版信息

Pan Afr Med J. 2019 Mar 25;32:141. doi: 10.11604/pamj.2019.32.141.17166. eCollection 2019.

DOI:10.11604/pamj.2019.32.141.17166

PMID:31308859

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6609855/

Abstract

INTRODUCTION

Sickle cell anaemia (SCA) is an inherited abnormality of haemoglobin associated with reduced life expectancy. Patients' complications include dyslipideamia. This study was aimed at determining the artherogenic index of plasma (AIP) in sickle cell anaemia patients and compares the value to HbAA controls value. A high AIP is strongly predictive of elevated cardiovascular risk.

METHODS

A comparative study was conducted among SCA patients attending the haematology clinic, Lagos State University Teaching Hospital (LASUTH) and HbAA Phenotype controls. A total of 304 participants were recruited consisting of equal numbers of SCA and HbAA controls. Single lipid profiles were done; logarithms of triglycerides/high density lipoprotein were calculated to obtain AIP and lipid profile ratios established for all participants.

RESULTS

There were lower mean values of Total Cholesterol (TC), High Density Lipoprotein(HDL) and Low Density Lipoprotein (LDL) amongst SCD participants than controls and higher mean values of triglycerides (TG) and Very Low Density Lipoprotein (VLDL) in SCD p < 0.05. The AIP in SCD ranges from -0.62 to 1.32 while that of controls ranges from -0.56 to 0.61.The mean AIP were 0.14 ± 0.29 and -0.009 ± 0.26 in SCD and controls respectively. P value = 0.002.

CONCLUSION

AIP value is higher in sickle cell anaemia than controls, the former have lower mean values of TC, HDL and LDL and higher mean values of TG and VLDL.

摘要

引言

镰状细胞贫血（SCA）是一种与预期寿命缩短相关的遗传性血红蛋白异常疾病。患者的并发症包括血脂异常。本研究旨在确定镰状细胞贫血患者的血浆致动脉粥样硬化指数（AIP），并将该值与HbAA对照值进行比较。高AIP强烈预示心血管风险升高。

方法

在拉各斯州立大学教学医院（LASUTH）血液科就诊的SCA患者和HbAA表型对照者中进行了一项比较研究。共招募了304名参与者，其中SCA患者和HbAA对照者数量相等。进行了单项血脂检测；计算甘油三酯/高密度脂蛋白的对数以获得AIP，并为所有参与者建立血脂比值。

结果

SCD参与者的总胆固醇（TC）、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）的平均值低于对照组，而SCD患者的甘油三酯（TG）和极低密度脂蛋白（VLDL）的平均值较高，p<0.05。SCD患者的AIP范围为-0.62至1.32，而对照组的AIP范围为-0.56至0.61。SCD患者和对照组的平均AIP分别为0.14±0.29和-0.009±0.26。P值=0.002。