Lundborg G, Hansson H A, Rank F, Rydevik B
J Hand Surg Am. 1980 Sep;5(5):451-61. doi: 10.1016/s0363-5023(80)80075-x.
Severed and subsequently sutured rabbit flexor tendons were kept free and isolated in the synovial cavity of the knee joint. In one series the tendon specimens were surrounded by a dialyzing membrane to avoid cell seeding from the synovial fluid. At different intervals of time over a period of 3 weeks, the tendons were studied morphologically with special reference to scanning electron microscopy. Adhesions were not observed and, with synovial fluid as the nutrient medium, the tendons showed an intrinsic ability to repair in the superficial layers, also bridging the suture gap. Moreover, cell seeding, mainly of macrophages, from the synovial fluid could be demonstrated on the very surface of the tendon. When this cell seeding was prevented, the fibroplasia in the superficial layer of the tendon did decrease slightly, but tendon cell morphology was that of active fibroblasts. The results support the concept that flexor tendons may show intrinsic fibroplasia when nourished by synovial fluid, while macrophages, mainly of extrinsic origin, contribute to restoration of the tendon surface.
将切断并随后缝合的兔屈肌腱游离并隔离于膝关节的滑膜腔内。在一组实验中，肌腱标本被透析膜包裹，以避免滑膜液中的细胞接种。在3周的不同时间间隔内，对肌腱进行形态学研究，特别参考扫描电子显微镜观察。未观察到粘连，并且以滑膜液作为营养培养基时，肌腱在表层显示出内在的修复能力，也能桥接缝合间隙。此外，在肌腱的表面可以证实主要来自滑膜液的细胞接种，主要是巨噬细胞。当这种细胞接种被阻止时，肌腱表层的纤维组织增生确实略有减少，但肌腱细胞形态为活跃的成纤维细胞形态。这些结果支持这样的概念，即当由滑膜液滋养时，屈肌腱可能显示出内在的纤维组织增生，而主要来源于外部的巨噬细胞有助于肌腱表面的修复。
