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膳食脂肪对血小板膜流动性的影响。

Effect of dietary fat on the fluidity of platelet membranes.

作者信息

Berlin E, Matusik E J, Young C

出版信息

Lipids. 1980 Aug;15(8):604-8. doi: 10.1007/BF02534188.

DOI:10.1007/BF02534188
PMID:7432105
Abstract

Dietary fat type was reflected in the phospholipid fatty acid composition of the plasma membrane of rabbit platelets and apparently controlled the fluidity of these membranes. Rabbits were maintained for 6 months on diets that varied in stearic and polyunsaturated fatty acids and thus had different potentials for thrombosis. Microviscosities at 37 C, calculated from the arisotropy of fluorescence from the probe 1,6-diphenyl-1,3,5-hexatriene, were 3.5, 3.4, 2.8 and 2.2 poise for platelet membranes isolated from rabbits whose only source of dietary fat was cocoa butter, milkfat, coconut oil, or corn oil, respectively. The relative findings of the membrane isolates were correlated with the polyunsaturated fatty acid contents of the membrane phospholipids.

摘要

膳食脂肪类型反映在兔血小板质膜的磷脂脂肪酸组成中,并且显然控制着这些膜的流动性。给兔子喂食硬脂酸和多不饱和脂肪酸含量不同、因而具有不同血栓形成潜力的饮食6个月。根据探针1,6 - 二苯基 - 1,3,5 - 己三烯荧光的各向异性计算得出,在37℃时,从仅以可可脂、乳脂、椰子油或玉米油为膳食脂肪来源的兔子中分离出的血小板膜的微粘度分别为3.5、3.4、2.8和2.2泊。膜分离物的相关研究结果与膜磷脂中的多不饱和脂肪酸含量相关。

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