Gościcki J, Woźniak H, Bielichowska G, Szendzikowski S, Lao I
Med Pr. 1980;31(3):185-94.
In animal experiments pneumoconiogenic properties of metallurgic and Portland cement dust, produced in Poland, were investigated. Experimental pneumoconiosis was developed by intratracheal single administration, to white rats, of 50 mg of dust suspended in 0.6 ml of NaCl physiological solution. The control groups were composed of animals to whom intratracheally physiological NaCl solution, TiO2 dust and two quartz dusts of varying fibrogenic properties--weak and mild, were administered. The content of crystalline silica, as determined chemically, was approx. 3% in both cement samples. X-ray diffraction did not show any content of crystalline phases in the cements, TiO2 dust contained rutile, whereas both quartz dusts contained about 100% alpha-quartz. After 3 months the animals were sacrificed. Wet lungs weight and hydroxyproline content in lungs were determined. In addition, mediastinal nodes and lungs were examined histologically. Cement dust was found to exhibit weak fibrogenic properties, not different significantly from fibrogenic properties of inert TiO2. Nevertheless increases in fibrogenic effect of cement dusts were significantly higher as compared to the control group (geometric mean hydroxyproline content in the control group was 2.52 +/- 0.06 mg, 4.50 +/- 0.09 in the Portland cement and 4.88 +/- 0.06 in metallurgic cement. Histological changes in lungs, due to cement effect are not progressive, expressing merely inflammatory reaction to dust. Nevertheless despite weak fibrogenic properties the cement dust provokes lesions of macrophages in lungs.
在动物实验中，对波兰生产的冶金水泥粉尘和波特兰水泥粉尘的致尘肺特性进行了研究。通过向白鼠气管内单次注入悬浮于0.6毫升氯化钠生理溶液中的50毫克粉尘，诱发实验性尘肺。对照组由气管内注入生理氯化钠溶液、二氧化钛粉尘以及两种具有不同纤维生成特性（弱和中等）的石英粉尘的动物组成。经化学测定，两种水泥样品中的结晶二氧化硅含量约为3%。X射线衍射显示水泥中不存在任何结晶相成分，二氧化钛粉尘含有金红石，而两种石英粉尘均含有约100%的α-石英。3个月后处死动物，测定湿肺重量和肺中羟脯氨酸含量。此外，对纵隔淋巴结和肺进行组织学检查。发现水泥粉尘具有较弱的纤维生成特性，与惰性二氧化钛的纤维生成特性无显著差异。然而，与对照组相比，水泥粉尘的纤维生成效应增加显著更高（对照组中羟脯氨酸含量的几何平均值为2.52±0.06毫克，波特兰水泥组为4.50±0.09毫克，冶金水泥组为4.88±。06毫克）。由于水泥作用导致的肺部组织学变化并不进行性发展，仅表现为对粉尘的炎症反应。然而，尽管纤维生成特性较弱，水泥粉尘仍会引发肺部巨噬细胞的损伤。
