[硅藻土与其他硅尘致纤维化特性的比较研究]

[Comparative studies on fibrogenic properties of diatomites and other silica dusts].

作者信息

Woźniak H

出版信息

Med Pr. 1983;34(5-6):427-34.

Abstract

The experiment carried out on animals was aimed at testing fibrogenic properties of two samples of the Carpathian diatomites and silica earth from Piotrowice. Experimental pneumoconiosis was induced by intratracheal administration of 50 mg of dust suspended in 0,6 ml of NaCl physiological solution to experimental animals (rats). The animals were killed after 3,6 and 9 months since dust administration and the examinations consisted in determination of wet lungs weight, hydroxyproline content in lungs, mediastinum nodes weight and lipids content. Comparison of the achieved results indicated that diatomites fibrogenic properties are many times lower than fibrogenic properties of silica earth. This fact, at similar physico-chemical properties of these raw materials, creates a possibility of elimination of workers exposure to highly aggressive silica earth dust by replacing it by diatomite.

摘要

在动物身上进行的实验旨在测试来自喀尔巴阡山脉的两种硅藻土样本以及皮奥特罗维采的硅土的纤维化特性。通过向实验动物（大鼠）气管内注射悬浮于0.6毫升氯化钠生理溶液中的50毫克粉尘来诱发实验性尘肺。在给予粉尘后的3个月、6个月和9个月处死动物，检查包括测定湿肺重量、肺中羟脯氨酸含量、纵隔淋巴结重量和脂质含量。对所得结果的比较表明，硅藻土的纤维化特性比硅土的纤维化特性低很多倍。在这些原材料具有相似物理化学性质的情况下，这一事实使得有可能用硅藻土替代硅土，从而消除工人接触极具侵蚀性的硅土粉尘的情况。