Walter P, Pusel J, Rousselot P
Pathol Res Pract. 1980;167(2-4):402-9. doi: 10.1016/s0344-0338(80)80070-7.
Neoplasms of the thyroid with multinucleated, osteoclast-like giant cells, are rare. The numerous giant cells observed in these undifferentiated neoplasm have extensive eosinophilic cytoplasm and contain two to several hundred round or oval, uniform small nuclei. The clinical and morphologic data obtained from the two cases we describe and seven others collected from the literature are as follows: a) peak incidence in late adulthood; b) frequent association with a preexisting goiter (6 cases); c) rapid growth and fatal outcome within one year following diagnosis (5 cases); d) histologic pleomorphism with a background of uniform and spindle- or bizarre-shaped mononuclear cells; e) occasional coexistence of multinucleated giant cell tumor with well differentiated follicular carcinoma (1 case). Indirect evidence suggests that the multinucleated giant cells which characterize these unusual anaplastic carcinomas are epithelial in origin.
伴有多核破骨细胞样巨细胞的甲状腺肿瘤很罕见。在这些未分化肿瘤中观察到的大量巨细胞具有广泛的嗜酸性细胞质，并且含有两到数百个圆形或椭圆形、大小一致的小细胞核。我们描述的两例病例以及从文献中收集的其他七例病例所获得的临床和形态学数据如下：a）发病高峰在成年晚期；b）常与既往存在的甲状腺肿相关（6例）；c）诊断后一年内生长迅速且预后不良（5例）；d）组织学多形性，背景为形态一致的梭形或怪异形单核细胞；e）偶尔多核巨细胞瘤与高分化滤泡癌共存（1例）。间接证据表明，这些不寻常的间变性癌所特有的多核巨细胞起源于上皮。
