Esmaili J H, Hafez G R, Warner T F
Cancer. 1983 Dec 1;52(11):2122-8. doi: 10.1002/1097-0142(19831201)52:11<2122::aid-cncr2820521125>3.0.co;2-3.
An unusual malignant thyroid neoplasm with a morphologic resemblance to giant cell tumor of the bone is reported in a patient who presented with a rapidly growing thyroid mass and a history of pre-existing goiter. The light and electron microscopic studies disclosed areas of differentiated follicular carcinoma with gradual transition to undifferentiated carcinoma. Pleomorphic spindle-shaped cells and giant cells were accompanied by numerous osteoclast-like multinucleated giant cells. Desmosomes and interdigitating cell surfaces were apparent in the differentiated as well as undifferentiated areas on electron microscopy. These findings support an epithelial rather than a mesenchymal origin for this neoplasm.
报告了一例罕见的恶性甲状腺肿瘤，其形态与骨巨细胞瘤相似。该患者甲状腺肿物迅速增大，既往有甲状腺肿病史。光镜和电镜研究显示，肿瘤有分化型滤泡癌区域，并逐渐过渡为未分化癌。多形性梭形细胞和巨细胞伴有大量破骨细胞样多核巨细胞。电镜下，在分化和未分化区域均可见桥粒和交错的细胞表面。这些发现支持该肿瘤起源于上皮而非间充质。
