Barac-Nieto M, Spurr G B, Dahners H W, Maksud M G
Am J Clin Nutr. 1980 Nov;33(11):2268-75. doi: 10.1093/ajcn/33.11.2268.
Oxygen consumption in maximal exercise (VO2max) was found to increase during nutritional rehabilitation of severely undernourished, sedentary adult males only when dietary protein was increased from 27 to 100 g/day. Adequate caloric intake, maintained for 45 days before the increase in protein content of the diet, had no effect on VO2max. The VO2max values were found to correlate best with the creatinine excretion rates (an index of the muscle cell mass) at the different stages of repletion. The average increment in VO2max/muscle cell mass ratio, although significant, was of a small magnitude (+15%). The VO2max/muscle cell mass ratio correlated only with the blood and plasma volumes at the different stages of repletion. After 2.5 months of protein repletion the VO2max values were still lower than those in mildly undernourished or normal Colombian adult males. Maximal endurance time at 80% aerobic load decreased significantly from an average of 113 min at the beginning of hospitalization to 42 min at the end of the period of protein repletion. This could be the result of replacing carbohydrate calories with protein in the diet, producing depletion of muscle glycogen stores, and/or to "detraining" effects associated with sedentary hospital life.
在对严重营养不良、久坐不动的成年男性进行营养康复期间，只有当膳食蛋白质摄入量从每天27克增加到100克时，最大运动耗氧量（VO2max）才会增加。在增加饮食蛋白质含量之前，维持45天的充足热量摄入对VO2max没有影响。发现在补充的不同阶段，VO2max值与肌酐排泄率（肌肉细胞质量的一个指标）的相关性最好。VO2max/肌肉细胞质量比的平均增量虽然显著，但幅度较小（+15%）。VO2max/肌肉细胞质量比仅与补充的不同阶段的血液和血浆量相关。蛋白质补充2.5个月后，VO2max值仍低于轻度营养不良或正常的哥伦比亚成年男性。在80%有氧负荷下的最大耐力时间从住院开始时的平均113分钟显著下降到蛋白质补充期结束时的42分钟。这可能是由于饮食中用蛋白质替代了碳水化合物热量，导致肌肉糖原储备耗尽，和/或与久坐的医院生活相关的“废用性萎缩”效应。
