Read D J, Matthews W B, Higson R H
Brain. 1980 Dec;103(4):803-33. doi: 10.1093/brain/103.4.803.
Eleven patients with static or slowly progressive multiple sclerosis were treated with continuous spinal cord stimulation via epidural electrodes for a minimum of two weeks. An extensive battery of objective tests was used to assess results. Significant improvement in urinary bladder function was seen in 2 of the patients with a lesser degree of improvement in 4 others and reduction of lower limb spasticity in 6 patients. Five additional patients selected for these disabilities were then treated with further evidence of improvement in bladder function in 4 and in lower limb spasticity in 2. It is suggested that benefit results from inhibition of excessive spinal reflex activity.
11例患有静止性或缓慢进展性多发性硬化症的患者通过硬膜外电极接受了至少两周的脊髓持续刺激治疗。使用了一系列广泛的客观测试来评估结果。2例患者膀胱功能有显著改善，另外4例有较小程度的改善，6例患者下肢痉挛减轻。另外5例因这些残疾入选的患者随后接受治疗，其中4例膀胱功能有进一步改善的证据，2例下肢痉挛有改善。有人认为，这种益处源于对过度脊髓反射活动的抑制。
