Underdahl N R, Kennedy G A, Ramos A S
Can Vet J. 1980 Sep;21(9):258-61.
Sixteen gnotobiotic pigs raised in flexible plastic isolators (four pigs per isolator) were inoculated with a culture of Mycoplasma hyopneumoniae. One pig was killed and underwent necropsy at weekly intervals for the following 16 weeks. Macroscopic lesions were observed in the lungs of 13 of 16 pigs and microscopic lesions were found in 14 of 16 pigs. Mycoplasma hyopneumoniae was cultured from the trachea or lungs from 10 of the 16 pigs. Scanning electron microscope studies showed areas of damage to the cilia, collections, of leucocytes and mucus, and mycoplasma in the trachea as well as the bronchi. These conditions were found in all the pigs seen at necropsy from nine to 16 weeks postinoculation and there was no evidence of noticeable regression or recovery during this 16 week period.
在柔性塑料隔离器中饲养的16头无菌猪（每个隔离器4头猪）接种了猪肺炎支原体培养物。在接下来的16周内，每周宰杀1头猪并进行尸检。16头猪中有13头的肺部观察到宏观病变，16头猪中有14头发现微观病变。16头猪中有10头的气管或肺部培养出猪肺炎支原体。扫描电子显微镜研究显示，接种后9至16周进行尸检的所有猪的气管和支气管中都存在纤毛损伤区域、白细胞和黏液聚集以及支原体。在这16周期间，没有明显的消退或恢复迹象。
