Romić-Stojković R, Gamulin S
Cancer Res. 1980 Dec;40(12):4821-5.
The qualitative and quantitative relationships between cytoplasmic estrogen receptors (ERC), total nuclear estrogen receptors (ERN), and cytoplasmic progesterone receptors (PGR) in 74 primary and 23 metastatic human breast cancer tissues were studied. A positive correlation between the age of th patients and the receptor concentration was found only for ERC. Although ERN and PGR were more frequent in tumors with a higher level of ERC, there was no significant correlation between concentrations of either ERN or PGR and ERC. However, PGR were more frequent in ERN-positive than in ERN-negative tumors, irrespective of the presence of ERC. There was also a highly significant correlation between PGR and ERN concentrations. These findings support the assumption that induction of PGR by estrogen in human breast cancer is mediated by a mechanism involving nuclear receptors. Therefore, the ERN assay might increase the validity of steroid receptor determination for prediction of hormonal sensitivity of human breast cancer.
研究了74例原发性和23例转移性人乳腺癌组织中细胞质雌激素受体（ERC）、总核雌激素受体（ERN）和细胞质孕酮受体（PGR）之间的定性和定量关系。仅在ERC方面发现患者年龄与受体浓度呈正相关。尽管在ERC水平较高的肿瘤中ERN和PGR更为常见，但ERN或PGR的浓度与ERC之间均无显著相关性。然而，无论ERC是否存在，PGR在ERN阳性肿瘤中比在ERN阴性肿瘤中更常见。PGR和ERN浓度之间也存在高度显著的相关性。这些发现支持这样一种假设，即雌激素在人乳腺癌中诱导PGR是通过一种涉及核受体的机制介导的。因此，ERN检测可能会提高类固醇受体测定对预测人乳腺癌激素敏感性的有效性。
