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Multi-step metabolic activation of benzene. Effect of superoxide dismutase on covalent binding to microsomal macromolecules, and identification of glutathione conjugates using high pressure liquid chromatography and field desorption mass spectrometry.

作者信息

Tunek A, Platt K L, Przybylski M, Oesch F

出版信息

Chem Biol Interact. 1980 Dec;33(1):1-17. doi: 10.1016/0009-2797(80)90040-x.

DOI:10.1016/0009-2797(80)90040-x
PMID:7438288
Abstract
摘要

相似文献

1
Multi-step metabolic activation of benzene. Effect of superoxide dismutase on covalent binding to microsomal macromolecules, and identification of glutathione conjugates using high pressure liquid chromatography and field desorption mass spectrometry.苯的多步代谢活化。超氧化物歧化酶对微粒体大分子共价结合的影响，以及使用高压液相色谱法和场解吸质谱法鉴定谷胱甘肽缀合物。
Chem Biol Interact. 1980 Dec;33(1):1-17. doi: 10.1016/0009-2797(80)90040-x.
2
Multi-step metabolic activation of benzene in rat liver microsomes.
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3
Detection and identification of sulfhydryl conjugates of rho-benzoquinone in microsomal incubations of benzene and phenol.
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4
Biotransformation of phenol to hydroquinone and catechol by rat liver microsomes.大鼠肝脏微粒体将苯酚生物转化为对苯二酚和邻苯二酚。
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5
Comparison of the metabolism of benzene and its metabolite phenol in rat liver microsomes.
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6
Microsomal metabolism of benzene to species irreversibly binding to microsomal protein and effects of modifications of this metabolism.苯的微粒体代谢生成与微粒体蛋白不可逆结合的物质以及这种代谢修饰的影响。
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7
Formation of nontoxic reactive metabolites of p-bromophenol. Identification of a new glutathione conjugate.
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8
The formation of chlorobenzene and benzene by the reductive metabolism of lindane in rat liver microsomes.
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9
DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene.DT-黄递酶和过氧化物酶会影响苯的主要代谢产物苯酚的代谢物的共价结合。
Mol Pharmacol. 1984 Jul;26(1):105-11.
10
Benzene and phenol metabolism by mouse and rat liver microsomes.小鼠和大鼠肝脏微粒体对苯和苯酚的代谢
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Multiple scan modes in the hybrid tandem mass spectrometric screening and characterization of the glutathione conjugate of 2-furamide.多种扫描模式在 2-呋喃甲酰胺半胱氨酸轭合物的混合串联质谱筛选和表征中的应用。
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3
Inhibition of human DNA topoisomerase II by hydroquinone and p-benzoquinone, reactive metabolites of benzene.
对苯二酚和对苯醌（苯的活性代谢产物）对人DNA拓扑异构酶II的抑制作用。
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Induction of granulocytic differentiation in a mouse model by benzene and hydroquinone.苯和对苯二酚在小鼠模型中诱导粒细胞分化
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Chromosome alterations in peripheral lymphocytes as indices of lifestyle and genotoxicity.外周淋巴细胞中的染色体改变作为生活方式和遗传毒性的指标。
Int Arch Occup Environ Health. 1993;65(1 Suppl):S37-41. doi: 10.1007/BF00381305.
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The toxicology of benzene.苯的毒理学
Environ Health Perspect. 1993 Apr;100:293-306. doi: 10.1289/ehp.93100293.
7
GC/MS determination of N-phenylvaline, a possible biomarker for benzene exposure in human hemoglobin by the "N-alkyl Edman method".采用“N-烷基埃德曼法”通过气相色谱/质谱联用技术测定N-苯基缬氨酸，其可能作为人体血红蛋白中苯暴露的生物标志物。
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9
Erythroid progenitor cells that survive benzene exposure exhibit greater resistance to the toxic benzene metabolites benzoquinone and hydroquinone.在接触苯后存活下来的红系祖细胞对苯的毒性代谢产物苯醌和对苯二酚表现出更强的抗性。
Arch Toxicol. 1994;68(9):535-40. doi: 10.1007/s002040050110.
10
Effect of occupational exposure to benzene on phytohaemagglutinin (PHA) stimulated lymphocytes in man.职业性接触苯对人外周血中植物血凝素（PHA）刺激淋巴细胞的影响。
Br J Ind Med. 1988 Aug;45(8):516-22. doi: 10.1136/oem.45.8.516.