Majekodunmi A A
Doc Ophthalmol. 1980 Oct 15;49(2):211-9. doi: 10.1007/BF01886619.
Five cases of Mooren's ulcer in young Nigerians seen over a 2-year period, in Lagos, healed after limbal conjunctivectomy. The maximum follow up in 2 cases was 2 years. Previous trauma or corneal foreign bodies as seen in four of our cases seem to suggest the precipitation of Mooren's ulcer by various ocular insults. We believe that collagenolytic activity of the conjunctiva plays a prominent role in the pathogenesis of the ulcer and is supported by this report in which our five cases healed after excision of the limbal conjunctiva. Helminthosis, found in four of our five patients with Mooren's ulcer in an endemic area, such as Nigeria may be an associated finding. The presence of lymphocytes and plasma cells in the histopathology of the excised tissue in one of our cases is suggestive of an autoimmune phenomenon in this disease.
在拉各斯，2年期间共接诊5例年轻尼日利亚患者的蚕蚀性角膜溃疡，行角膜缘结膜切除术后均愈合。其中2例最长随访时间为2年。我们的4例患者既往有外伤或角膜异物史，这似乎提示各种眼外伤可诱发蚕蚀性角膜溃疡。我们认为结膜的胶原溶解活性在溃疡发病机制中起重要作用，本报告中5例患者切除角膜缘结膜后愈合也支持这一观点。在尼日利亚这样的流行地区，我们5例蚕蚀性角膜溃疡患者中有4例发现有蠕虫感染，这可能是相关发现。我们其中1例患者切除组织的组织病理学检查显示有淋巴细胞和浆细胞，提示该病存在自身免疫现象。
