Degtiarev V P
Farmakol Toksikol. 1980 Jul-Aug;43(4):360-3.
The effect of the M-cholinomimetic arecoline and M-cholinolytic metamizil, n-cholinomimetic lobelin and n-cholinolytic -506 (beta-ethylenespasmolytin) on the formation of nociceptive responses induced by dental pulp stimulation was studied by means of microinjections into the rabbit thalamus preparations VPM and VPL. Arecoline and -506 decreased while metamizil and lobelin increased the amplitude of the primary responses. No changes in the latent periods were noted. It is concluded that the activation of the M-cholinergic structures of specific nuclei of the thalamus reduces the nociceptive responses. The activation of the N-cholinergic structures potentiates the nociceptive responses in specific relays.
通过向兔丘脑腹后内侧核（VPM）和腹后外侧核（VPL）制备物中微量注射，研究了M胆碱能拟似物槟榔碱、M胆碱能阻断剂安乃近、N胆碱能拟似物洛贝林和N胆碱能阻断剂β-乙撑解痉素对牙髓刺激诱导的伤害性反应形成的影响。槟榔碱和β-乙撑解痉素降低了初级反应的幅度，而安乃近和洛贝林增加了初级反应的幅度。潜伏期未见变化。得出结论：丘脑特定核团的M胆碱能结构激活可降低伤害性反应。N胆碱能结构的激活增强了特定中继中的伤害性反应。
