Laitio M
Beitr Pathol. 1976 Jul;158(2):159-72.
The material consisted of 12 gallbladder carcinomas, all in their early phases. Ten of the patients were female, two were male. The mean age of the patients was 65 years, and the mean lifetime after operation was as short as five months. The purpose of this study was to obtain further information on the significance of metaplastic mucosal islands in the histogenesis of gallbladder carcinomas by investigating incipient carcinomas and the conditions of the adjacent mucosa. The investigation revealed goblet cells and enterochromaffin cells outside the tumour in four specimens, antral-type glands in ten specimens, gastric-type superficial epithelial islands in all twelve specimens. In eight cases there was an antral-type mucosal island outside the tumour. In six specimens the tumour was found to border on antral-type mucosa. The structure of the tumour was papillary in ten cases, and mucinous in two. The tumorous epithelium showed in all specimens focal intestinal-type areas. Six tumours displayed goblet cells, and enterochromaffin cells were present in four tumours. The two mucinous tumours seemed to have originated in the glands of the antral-type mucosa extending toward the serosal surface of the gallbladder wall. This study supports the theory suggesting a significance of metaplasia in the histogenesis of gallbladder tumours.
该材料包括12例处于早期阶段的胆囊癌。其中10例患者为女性，2例为男性。患者的平均年龄为65岁，术后平均生存期短至5个月。本研究的目的是通过研究早期癌及相邻黏膜的情况，进一步了解化生黏膜岛在胆囊癌组织发生中的意义。调查发现，4份标本中肿瘤外有杯状细胞和肠嗜铬细胞，10份标本中有胃窦型腺体，所有12份标本中均有胃型浅表上皮岛。8例在肿瘤外有胃窦型黏膜岛。6份标本中肿瘤与胃窦型黏膜相邻。10例肿瘤结构为乳头状，2例为黏液性。所有标本中肿瘤上皮均显示局灶性肠型区域。6例肿瘤有杯状细胞，4例肿瘤有肠嗜铬细胞。这2例黏液性肿瘤似乎起源于向胆囊壁浆膜面延伸的胃窦型黏膜腺体。本研究支持化生在胆囊肿瘤组织发生中有意义这一理论。
