Abel L A, Schmidt D, Dell'Osso L F, Daroff R B
Ann Neurol. 1978 Oct;4(4):313-8. doi: 10.1002/ana.410040405.
A subject with a medial rectus paresis secondary to a partial third nerve palsy was forced to use the affected eye for six days while the good eye was constantly patched. Saccadic eye movements were carefully measured each day; the grain increased, with a time constant of 0.85 day. The patch was then switched to the paretic eye and the gain decreased, with a time constant of 0.85 day. The patch was then switched to the paretic eye and the gain decreased, with a time constant of 1.54 days. This demonstrated central nervous system plasticity of the pulse and step of neural activity responsible for the generation of saccades in the adult human. In addition to gain changes, postsaccadic drift velocity and saccadic velocity/amplitude relationship alterations during the patching are reported. A major conclusion that can be drawn from analysis fo these data is that the gain changing is accomplished by pulse width changes rather than pulse height (firing frequency), which was not markedly altered.
一名因部分动眼神经麻痹继发内直肌麻痹的受试者，在好眼持续被遮盖的情况下，被迫使用患眼六天。每天仔细测量眼球的扫视运动；增益增加，时间常数为0.85天。然后将眼罩换到麻痹眼，增益下降，时间常数为0.85天。然后再次将眼罩换到麻痹眼，增益下降，时间常数为1.54天。这证明了成人大脑中负责扫视运动产生的神经活动的脉冲和阶跃的中枢神经系统可塑性。除了增益变化外，还报告了遮盖期间扫视后漂移速度和扫视速度/幅度关系的改变。从这些数据分析中可以得出的一个主要结论是，增益变化是通过脉冲宽度变化而不是脉冲高度（放电频率）实现的，脉冲高度没有明显改变。
