Wang S R, Zweiman B
Immunopharmacology. 1980 Apr;2(2):95-101. doi: 10.1016/0162-3109(80)90001-6.
Lymphocytes obtained from normal volunteers 4 hr after intravenous methylprednisolone (1 mg/kg of body weight) were significantly less stimulated in vitro by several concentrations of phytohemagglutinin and concanavalin A. This effect was not due to diurnal variations. Significant decreases in the levels of circulating T lymphocytes (p < 0.001) at this time suggested cellular redistribution as a factor in decreased mitogen responsiveness. However, incubation of plasma, obtained 1 hr after methylprednisolone injection, with normal autologous lymphocytes suppressed the in vitro responses as well, indicating an additional direct corticosteroid effect on the lymphocytes.
从正常志愿者静脉注射甲基强的松龙（1毫克/千克体重）4小时后获取的淋巴细胞，在体外受到几种浓度的植物血凝素和刀豆球蛋白A刺激的程度明显降低。这种效应并非由于昼夜变化所致。此时循环T淋巴细胞水平显著下降（p < 0.001），提示细胞重新分布是有丝分裂原反应性降低的一个因素。然而，甲基强的松龙注射1小时后获取的血浆与正常自体淋巴细胞一起孵育，也抑制了体外反应，表明皮质类固醇对淋巴细胞还有额外的直接作用。
