Zweiman B, Atkins P C, Bedard P M, Flaschen S L, Lisak R P
J Clin Immunol. 1984 Mar;4(2):151-5. doi: 10.1007/BF00915049.
The effects of in vivo corticosteroid administration on levels of lymphocyte subsets in normal humans require further definition. Using monoclonal antibodies, we carried out a double-blind, placebo-controlled study of oral and intravenous methylprednisolone in 10 normal volunteers. Four hours after a 7-day oral course of 0.5 mg/kg/day, there was modest lymphopenia but no significant selective alteration in lymphocyte subsets. In contrast, 4 hr after a single intravenous injection of 1.0 mg/kg, there was more pronounced lymphopenia (P less than 0.01), a selective, relative decrease in T4 cells (P less than 0.001), and a more modest decrease in the percentage of T3 cells. The possible mechanisms and implication of these changes are discussed.
体内给予皮质类固醇对正常人体内淋巴细胞亚群水平的影响尚需进一步明确。我们使用单克隆抗体，对10名正常志愿者进行了一项口服和静脉注射甲泼尼龙的双盲、安慰剂对照研究。在每日口服0.5mg/kg、持续7天的疗程结束4小时后，出现了轻度淋巴细胞减少，但淋巴细胞亚群无明显选择性改变。相比之下，单次静脉注射1.0mg/kg后4小时，淋巴细胞减少更为明显（P<0.01），T4细胞选择性相对减少（P<0.001），T3细胞百分比也有较轻度下降。本文讨论了这些变化的可能机制及意义。
