Mukherji S K, Schiro S, Castillo M, Kwock L, Soper R, Blackstock W, Shockley W, Weissler M
Department of Radiology, University of North Carolina, Chapel Hill, USA.
AJNR Am J Neuroradiol. 1996 Sep;17(8):1485-90.
To determine the ability of in vitro high-field-strength proton MR spectroscopy to differentiate squamous cell carcinoma of the upper aerodigestive tract from uninvolved muscle.
Surgical specimens of squamous cell carcinoma arising from the upper aerodigestive tract (n = 18) and from muscle (n = 13) were examined in vitro using high-field (11 T) proton MR spectroscopy. The peak heights of choline and creatine were measured for tumor and muscle at echo times of 136 and 272. The choline/creatine (Cho/Cr) ratio was compared between tumor and normal tissue for each echo time. Student's t test was used to determine whether a significant difference existed between proton MR spectroscopic measurements of the Cho/Cr ratio for tumor and muscle.
The mean Cho/Cr ratio was consistently higher in tumor than in muscle at all echo times; however, statistically significant differences between tumor and muscle were identified only at longer echo times (136 and 272).
The Cho/Cr peak height ratio can be used to differentiate tumor from muscle in vitro (at 11 T).
确定体外高场强质子磁共振波谱技术区分上呼吸消化道鳞状细胞癌与未受累肌肉的能力。
使用高场（11 T）质子磁共振波谱技术对取自上呼吸消化道的鳞状细胞癌手术标本（n = 18）和取自肌肉的手术标本（n = 13）进行体外检查。在回波时间为136和272时测量肿瘤和肌肉中胆碱和肌酸的峰高。比较每个回波时间肿瘤组织与正常组织之间的胆碱/肌酸（Cho/Cr）比值。采用学生t检验确定肿瘤与肌肉的质子磁共振波谱测量的Cho/Cr比值之间是否存在显著差异。
在所有回波时间，肿瘤的平均Cho/Cr比值始终高于肌肉；然而，仅在较长回波时间（136和272）时，肿瘤与肌肉之间存在统计学显著差异。
Cho/Cr峰高比值可用于在体外（11 T）区分肿瘤与肌肉。
