Omura S, Kitao C, Tanaka H, Oiwa R, Takahashi Y
J Antibiot (Tokyo). 1976 Sep;29(9):876-81. doi: 10.7164/antibiotics.29.876.
Asukamycin, a new antibiotic, has been isolated from the culture broth of a streptomycete designated as Streptomyces nodosus subsp. asukaensis. The antibiotic inhibits the growth of Gram-positive bacteria including Nocardia asteroides. The empirical formula of antibiotic asukamycin has been proposed as C29H22N2O9 (M.W. 542). An acute toxicity of the antibiotic in mice is LD50 48.5 mg/kg by intraperitoneal injection and it has no effect on mice when it was administered by 450 mg/kg per os.
明日霉素是一种新抗生素，从一株命名为明日星状链霉菌的链霉菌培养液中分离得到。该抗生素可抑制包括星状诺卡菌在内的革兰氏阳性菌的生长。明日霉素抗生素的经验式为C29H22N2O9（分子量542）。该抗生素对小鼠的急性毒性经腹腔注射的半数致死量为48.5 mg/kg，经口给予450 mg/kg时对小鼠无影响。
