Anke H, Schwab H, Achenbach H
J Antibiot (Tokyo). 1980 Sep;33(9):931-9. doi: 10.7164/antibiotics.33.931.
When Aspergillus panamensis, CBS 120.45, was grown on a medium with high carbon and low nitrogen content, it was found to produce six antibiotically active metabolites. All compounds were identified as tetronic acid derivatives; three of them were found to be identical with gregatins A, B, and D, previously reported as metabolites of Cephalosporium gregatum. The other three compounds are new. All six compounds show antibacterial activity towards Gram-negative and Gram-positive bacteria. Five of the antibiotics exhibit inhibitory effects on the macromolecular syntheses in cells of the ascitic form of EHRLICH carcinoma (ECA) of mice.
当巴拿马曲霉CBS 120.45在高碳低氮含量的培养基上生长时，发现它能产生六种具有抗菌活性的代谢产物。所有化合物均被鉴定为特窗酸衍生物；其中三种被发现与先前报道的作为聚多曲霉代谢产物的格雷加汀A、B和D相同。另外三种化合物是新的。所有六种化合物对革兰氏阴性菌和革兰氏阳性菌均表现出抗菌活性。其中五种抗生素对小鼠艾氏腹水癌（ECA）细胞的大分子合成具有抑制作用。
