克林霉素、氯霉素及替卡西林分别与庆大霉素联合用于治疗腹腔内感染和女性生殖道败血症的前瞻性随机对照研究。

Prospective, randomized comparative study of clindamycin, chloramphenicol, and ticarcillin, each in combination with gentamicin, in therapy for intraabdominal and female genital tract sepsis.

作者信息

Harding G K, Buckwold F J, Ronald A R, Marrie T J, Brunton S, Koss J C, Gurwith M J, Albritton W L

出版信息

J Infect Dis. 1980 Sep;142(3):384-93. doi: 10.1093/infdis/142.3.384.

DOI:10.1093/infdis/142.3.384

Abstract

The results of a prospective, randomized comparative study of the efficacy and toxicity of clindamycin, chloramphenicol, and ticarcillin in the treatment, concomitantly with gentamicin to ensure complete aerobic coverage, of 175 patients with serious mixed aerobic/anaerobic intraabdominal or female genital tract sepsis are reported. In the group with intraabdominal sepsis, 33 (79%) of 42 treated with clindamycin, 43 (81%) of 53 treated with chloramphenicol, and 35 (90%) of 39 treated with ticarcillin were cured. In the group with genital tract sepsis, 16 (94%) of 17 treated with clindamycin, 11 (100%) of 11 treated with chloramphenicol, and 12 (92%) of 13 treated with ticarcillin were cured. Diarrhea occurred most frequently in patients treated with clindamycin (P < 0.001), hematologic suppression occurred most frequently in patients treated with chloramphenicol (P < 0.01), and hypokalemia occurred most frequently in patients treated with ticarcillin (P < 0.01). Clindamycin, chloramphenicol, and ticarcillin, each in combination with gentamicin, are equally effective in therapy for intraabdominal or female genital tract sepsis.

摘要

报告了一项前瞻性随机对照研究的结果，该研究旨在比较克林霉素、氯霉素和替卡西林在联合庆大霉素以确保完全覆盖需氧菌的情况下，对175例患有严重需氧菌/厌氧菌混合性腹腔内或女性生殖道败血症患者的疗效和毒性。在腹腔内败血症组中，42例接受克林霉素治疗的患者中有33例（79%）治愈，53例接受氯霉素治疗的患者中有43例（81%）治愈，39例接受替卡西林治疗的患者中有35例（90%）治愈。在生殖道败血症组中，17例接受克林霉素治疗的患者中有16例（94%）治愈，11例接受氯霉素治疗的患者中有11例（100%）治愈，13例接受替卡西林治疗的患者中有12例（92%）治愈。腹泻在接受克林霉素治疗的患者中最常发生（P<0.001），血液学抑制在接受氯霉素治疗的患者中最常发生（P<0.01），低钾血症在接受替卡西林治疗的患者中最常发生（P<0.01）。克林霉素、氯霉素和替卡西林分别与庆大霉素联合使用，在治疗腹腔内或女性生殖道败血症方面同样有效。