头孢西丁联合或不联合阿米卡星与克林霉素加阿米卡星治疗外科脓毒症的随机对照研究
A randomized comparison of cefoxitin with or without amikacin and clindamycin plus amikacin in surgical sepsis.
作者信息
Tally F P, McGowan K, Kellum J M, Gorbach S L, O'Donnell T F
出版信息
Ann Surg. 1981 Mar;193(3):318-23. doi: 10.1097/00000658-198103000-00011.
The efficacy of cefoxitin, either alone or in combination (+/-) with an aminoglycoside was compared with clindamycin plus (+), an aminoglycoside for the treatment of mixed aerobic-anaerobic surgical infections, in a prospective randomized single blinded study. One hundred patients were entered into the study; 37 patients were assessable for clinical outcome in both groups, while toxicity could be assessed in 46 patients in the cefoxitin group and 47 in the clindamycin group. The groups were evenly matched considering age, sex, and type of infection. Favorable clinical responses were achieved in 34 of 37 patients treated with cefoxitin +/- amikacin, and 29 of 37 patients treated with clindamycin + amikacin; there was no statistical difference between the groups (p greater than 0.1). The incidences of toxicity were the same. Our study has demonstrated that cefoxitin with or without an aminoglycoside is as effective as clindamycin plus an aminoglycoside in the therapy of serious mixed infections in surgical patients.
在一项前瞻性随机单盲研究中，将头孢西丁单独使用或与氨基糖苷类联合使用（±）的疗效，与克林霉素加（+）氨基糖苷类治疗需氧-厌氧混合性外科感染的疗效进行了比较。100名患者进入该研究；两组中有37名患者可评估临床结局，而头孢西丁组46名患者和克林霉素组47名患者可评估毒性。考虑到年龄、性别和感染类型，两组匹配良好。使用头孢西丁±阿米卡星治疗的37名患者中有34名获得了良好的临床反应，使用克林霉素+阿米卡星治疗的37名患者中有29名获得了良好的临床反应；两组之间无统计学差异（p大于0.1）。毒性发生率相同。我们的研究表明，有或没有氨基糖苷类的头孢西丁在治疗外科患者严重混合感染方面与克林霉素加氨基糖苷类一样有效。
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