Costa M L, Penido E, Costa S O
J Gen Microbiol. 1980 Jun;118(2):543-7. doi: 10.1099/00221287-118-2-543.
The addition of subinhibitory concentrations (optimal 1.8 mg ml-1) of guanidine hydrochloride to broth cultures of three strains of Staphylococcus aureus was followed by loss of penicillin and cadmium resistance. The proportion of sensitive variants, although variable, was higher than in untreated cultures. The 'penicillinase plasmid' was absent from two cultures sensitive to penicillin and cadmium. The genes for penicillinase production in one culture (13136) were apparently carried by a plasmid of 105 x 10(6) daltons.
在三种金黄色葡萄球菌的肉汤培养物中添加亚抑制浓度（最佳浓度为1.8毫克/毫升）的盐酸胍后，菌株对青霉素和镉的抗性丧失。敏感变体的比例虽然有所变化，但高于未处理的培养物。两种对青霉素和镉敏感的培养物中不存在“青霉素酶质粒”。在一种培养物（13136）中，产生青霉素酶的基因显然由一个105×10⁶道尔顿的质粒携带。
