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肝癌脂质中异常十六碳烯酸脂肪酸的出现。

Occurrence of unusual hexadecenoate fatty acids in hepatoma lipids.

作者信息

Wood R, Lee T

出版信息

Lipids. 1980 Oct;15(10):876-9. doi: 10.1007/BF02534380.

DOI:10.1007/BF02534380
PMID:7442477
Abstract

Cis-hexadecenoates isolated from rat liver and hepatoma 7288CTC lipids were analyzed for positional isomers by ozonolysis and capillary gas liquid chromatography. In addition to the delta 6, delta 7, delta 9 and delta 11 isomers found in both tissues, the hepatoma neutral and polar lipids contained relatively high percentages of delta 12 and delta 14 hexadecenoates that were virtually absent from liver. The occurrence of these unusual fatty acids may result from an error in lipid metabolism in the hepatoma.

摘要

从大鼠肝脏和肝癌7288CTC脂质中分离出的顺式十六碳烯酸酯,通过臭氧分解和毛细管气液色谱法分析其位置异构体。除了在两种组织中都发现的δ6、δ7、δ9和δ11异构体之外,肝癌的中性和极性脂质中含有相对较高百分比的δ12和δ14十六碳烯酸酯,而这些在肝脏中几乎不存在。这些异常脂肪酸的出现可能是由于肝癌中脂质代谢错误导致的。

相似文献

1
Occurrence of unusual hexadecenoate fatty acids in hepatoma lipids.肝癌脂质中异常十六碳烯酸脂肪酸的出现。
Lipids. 1980 Oct;15(10):876-9. doi: 10.1007/BF02534380.
2
Incorporation of dietary cis and trans isomers of octadecenoate in lipid classes of liver and hepatoma.肝脏和肝癌脂质类别中膳食十八碳烯酸顺式和反式异构体的掺入。
J Biol Chem. 1977 Mar 25;252(6):1965-70.
3
Geometrical and positional isomer content of the monounsaturated fatty acids from various rat tissues.
Lipids. 1979 Sep;14(9):789-94. doi: 10.1007/BF02533517.
4
Effect of methyl 2-hexadecynoate on hepatic fatty acid metabolism.2-十六碳炔酸甲酯对肝脏脂肪酸代谢的影响。
Lipids. 1980 Mar;15(3):141-50. doi: 10.1007/BF02540960.
5
Membrane lipids of hepatic tissue. II. Phospholipids from subcellular fractions of liver and hepatoma 7288CTC.肝组织的膜脂。II. 来自肝脏和肝癌7288CTC亚细胞组分的磷脂
J Natl Cancer Inst. 1983 Mar;70(3):567-73.
6
Distribution of hexadecenoic, octadecenoic and octadecadienoic acid isomers in human tissue lipids.
Lipids. 1986 Sep;21(9):543-7. doi: 10.1007/BF02534049.
7
Membrane lipids of hepatic tissue. I. Neutral lipids from subcellular fractions of liver and hepatoma 7288CTC.肝组织的膜脂。I. 来自肝脏和肝癌7288CTC亚细胞组分的中性脂类
J Natl Cancer Inst. 1983 Mar;70(3):559-66.
8
A comparison of lipids from liver and hepatoma subcellular membranes.来自肝脏和肝癌亚细胞膜的脂质比较。
Lipids. 1986 Apr;21(4):292-300. doi: 10.1007/BF02536416.
9
Effect of hepatoma on host liver, heart and lung lipids as tumor growth progresses.随着肿瘤生长进展,肝癌对宿主肝脏、心脏和肺脂质的影响。
Lipids. 1982 Nov;17(11):771-9. doi: 10.1007/BF02535353.
10
Occurrence of geometrical isomers of eicosapentaenoic and docosahexaenoic acids in liver lipids of rats fed heated linseed oil.喂食加热亚麻籽油的大鼠肝脏脂质中二十碳五烯酸和二十二碳六烯酸几何异构体的出现情况。
Lipids. 1989 Sep;24(9):799-804. doi: 10.1007/BF02544587.

本文引用的文献

1
SYNTHESIS OF FATTY ACIDS IN ANIMAL TISSUES. II. THE OCCURRENCE AND BIOSYNTHESIS OF CIS-VACCENIC ACID.动物组织中脂肪酸的合成。II. 顺式- vaccenic酸的存在与生物合成。
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Investigation on lipid separation methods. Separation of phospholipids from neutral fat and fatty acids.脂质分离方法的研究。从中性脂肪和脂肪酸中分离磷脂。
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Effect of methyl 2-hexadecynoate on hepatic fatty acid metabolism.2-十六碳炔酸甲酯对肝脏脂肪酸代谢的影响。
Lipids. 1980 Mar;15(3):141-50. doi: 10.1007/BF02540960.
5
The effect of a fat free diet on esterified monoenoic fatty acid isomers in rat tissues.
Lipids. 1971 Nov;6(11):831-5. doi: 10.1007/BF02531213.
6
Lipids of cultured hepatoma cells: V. Distribution of isomeric monoene fatty acids in individual lipid classes.培养的肝癌细胞的脂质:V. 异构单烯脂肪酸在各个脂质类别中的分布。
Lipids. 1974 Dec;9(12):987-92. doi: 10.1007/BF02533823.
7
Lipids of cultured hepatoma cells: IV. Effect of serum and lipid upon cellular and media neutral lipids.培养的肝癌细胞的脂质:IV. 血清和脂质对细胞及培养基中性脂质的影响。
Lipids. 1974 Dec;9(12):979-86. doi: 10.1007/BF02533822.
8
Lipids of cultured hepatoma cells. 3. Triglyceride and phosphoglyceride biosynthesis in minimal deviation hepatoma 7288C.培养的肝癌细胞的脂质。3. 最小偏离肝癌7288C中甘油三酯和磷酸甘油酯的生物合成。
Lipids. 1974 Mar;9(3):141-8. doi: 10.1007/BF02532685.
9
Geometrical and positional isomer content of the monounsaturated fatty acids from various rat tissues.
Lipids. 1979 Sep;14(9):789-94. doi: 10.1007/BF02533517.
10
Incorporation of dietary cis and trans isomers of octadecenoate in lipid classes of liver and hepatoma.肝脏和肝癌脂质类别中膳食十八碳烯酸顺式和反式异构体的掺入。
J Biol Chem. 1977 Mar 25;252(6):1965-70.