含N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺（MDP）的缀合物的合成。它们作为半抗原-载体系统的用途。 - Suppr

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超能文献

Synthesis of conjugates containing N-acetylmuramyl-L-alanyl-D-isoglutaminyl (MDP). Their use as hapten-carrier systems.

作者信息

Reichert C M, Carelli C, Jolivet M, Audibert F, Lefrancier P, Chedid L

出版信息

Mol Immunol. 1980 Mar;17(3):357-63. doi: 10.1016/0161-5890(80)90056-5.

DOI:10.1016/0161-5890(80)90056-5

PMID:7442679

Abstract

摘要

相似文献

Synthesis of conjugates containing N-acetylmuramyl-L-alanyl-D-isoglutaminyl (MDP). Their use as hapten-carrier systems.含N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺（MDP）的缀合物的合成。它们作为半抗原-载体系统的用途。

Mol Immunol. 1980 Mar;17(3):357-63. doi: 10.1016/0161-5890(80)90056-5.

Analysis of the antigenic relationship of various derivatives of n-acetyl-muramyl-l-ala-d-isoglutamine (MDP), using anti-MDP antibodies.使用抗MDP抗体分析N-乙酰-胞壁酰-L-丙氨酰-D-异谷氨酰胺（MDP）各种衍生物的抗原关系。

Mol Immunol. 1982 May;19(5):737-45. doi: 10.1016/0161-5890(82)90375-3.

Immunoadjuvant effects of the synthetic muramyl-dipeptide (MDP) N-acetylmuramyl-L-alanyl-D-isoglutamine.合成的胞壁酰二肽（MDP）N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺的免疫佐剂作用。

Z Immunitatsforsch Immunobiol. 1978 Oct;155(1):87-92.

Efficient genetically controlled formation of antibody to a synthetic antigen [poly(LTyr, LGlu)-poly(DLAla)- -poly(LLys)] covalently bound to a synthetic adjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine).高效地通过基因控制形成针对与合成佐剂（N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺）共价结合的合成抗原[聚（L-酪氨酸，L-谷氨酸）-聚（D-丙氨酸）-聚（L-赖氨酸）]的抗体。

Proc Natl Acad Sci U S A. 1980 Aug;77(8):4933-7. doi: 10.1073/pnas.77.8.4933.

Past, present and future of the synthetic immunoadjuvant MDP and its analogs.合成免疫佐剂MDP及其类似物的过去、现在与未来

Biochem Pharmacol. 1978;27(18):2183-6. doi: 10.1016/0006-2952(78)90074-6.

[Biological properties of synthetic glycopeptides stimulating immunogenesis and nonspecific resistance].[刺激免疫发生和非特异性抵抗力的合成糖肽的生物学特性]

Zh Mikrobiol Epidemiol Immunobiol. 1981(8):13-8.

Adjuvant activity of carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine in guinea pigs.N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺的碳水化合物类似物对豚鼠中偶氮苯砷酸盐-N-乙酰-L-酪氨酸迟发型超敏反应诱导的佐剂活性。

Infect Immun. 1981 Sep;33(3):834-9. doi: 10.1128/iai.33.3.834-839.1981.

Biological studies of lipophilic MDP-derivatives incorporated in liposomes.脂质体包裹的亲脂性MDP衍生物的生物学研究。

Immunol Commun. 1981;10(6):511-22. doi: 10.3109/08820138109055701.

A novel immunostimulator, N-[alpha-O-benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl]-N6-trans-(m-nitrocinnamoyl)-L-lysine, and its adjuvancy on the hepatitis B surface antigen.一种新型免疫刺激剂，N-[α-O-苄基-N-(乙酰胞壁酰)-L-丙氨酰-D-异谷氨酰胺基]-N6-反式-(间硝基肉桂酰)-L-赖氨酸，及其对乙型肝炎表面抗原的佐剂作用。

J Med Chem. 2005 Aug 11;48(16):5112-22. doi: 10.1021/jm0493313.

Inhibitory and stimulatory effects of a synthetic glycopeptide (MDP) on the in vitro PFC response: factors affecting the response.一种合成糖肽（MDP）对体外PFC反应的抑制和刺激作用：影响该反应的因素

Cell Immunol. 1979 Feb;42(2):336-43. doi: 10.1016/0008-8749(79)90199-0.

引用本文的文献

Extraintestinal manifestations of granulomatous enterocolitis induced in rabbits by long-term submucosal administration of muramyl dipeptide emulsified with Freund's incomplete adjuvant.长期经黏膜下给予用弗氏不完全佐剂乳化的胞壁酰二肽诱导兔产生肉芽肿性小肠结肠炎的肠外表现。

J Gastroenterol. 1996 Apr;31(2):199-206. doi: 10.1007/BF02389518.

Muramyl peptides. Chemical structure, biological activity and mechanism of action.胞壁酰肽。化学结构、生物活性及作用机制。

Mol Cell Biochem. 1981 Dec 4;41:27-47. doi: 10.1007/BF00225295.

Antiviral response elicited by a completely synthetic antigen with built-in adjuvanticity.由具有内在佐剂活性的完全合成抗原引发的抗病毒反应。

Proc Natl Acad Sci U S A. 1980 Nov;77(11):6769-72. doi: 10.1073/pnas.77.11.6769.

Absence of antibodies to muramyl dipeptide in patients with tuberculosis or leprosy.结核病或麻风病患者中缺乏针对胞壁酰二肽的抗体。

Clin Exp Immunol. 1982 Jan;47(1):53-8.

Immunological castration of male mice by a totally synthetic vaccine administered in saline.通过在盐水中注射完全合成疫苗对雄性小鼠进行免疫去势。

Proc Natl Acad Sci U S A. 1982 Sep;79(17):5392-5. doi: 10.1073/pnas.79.17.5392.

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