结核病或麻风病患者中缺乏针对胞壁酰二肽的抗体。
Absence of antibodies to muramyl dipeptide in patients with tuberculosis or leprosy.
作者信息
Bahr G M, Modabber F Z, Rook G A, Mehrotra M L, Stanford J L, Chedid L
出版信息
Clin Exp Immunol. 1982 Jan;47(1):53-8.
Abstract
The enzyme-linked immunosorbent assay (ELisa) was used to detect the presence of antibodies to muramyl dipeptide (MDP) in serum of patients with leprosy or tuberculosis. Using a conjugate of MDP-lysine to horse radish peroxidase, no such antibodies could be detected in sera of either patients or controls. Antibodies to a sonicate antigen of Mycobacterium tuberculosis were found in sera of all individuals tested and the binding of these antibodies to the M. tuberculosis antigen could not be inhibited by MDP. On the other hand, binding of MDP to anti-MDP antibodies, raised in rabbits, was largely inhibited by free MDP, slightly inhibited by M. tuberculosis antigen and was not inhibited by the patients' sera.
摘要
采用酶联免疫吸附测定（ELISA）检测麻风病或结核病患者血清中针对胞壁酰二肽（MDP）的抗体。使用MDP-赖氨酸与辣根过氧化物酶的偶联物，在患者或对照的血清中均未检测到此类抗体。在所有检测个体的血清中均发现了针对结核分枝杆菌超声破碎抗原的抗体，并且这些抗体与结核分枝杆菌抗原的结合不能被MDP抑制。另一方面，在兔体内产生的抗MDP抗体与MDP的结合在很大程度上被游离MDP抑制，被结核分枝杆菌抗原轻微抑制，且不被患者血清抑制。
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