• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

N-[N'-(2-氯乙基)-N'-亚硝基氨基甲酰基]-氨基酸酯和酰胺的抗肿瘤活性

Antineoplastic activity of esters and amides of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-aminoacids.

作者信息

Zeller W J, Ehresmann K, Eisenbrand G

出版信息

J Cancer Res Clin Oncol. 1984;108(2):249-51. doi: 10.1007/BF00402478.

DOI:10.1007/BF00402478
PMID:6470033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12253009/
Abstract

The antineoplastic activity of 7 ester derivatives and 15 amide derivatives of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl (CNC)]-aminoacids was examined in transplanted rat leukemia L 5222. All esters except the ethylester of CNC-L-isoleucine showed only a moderate antitumor activity. CNC-L-isoleucine ethylester effected some cures and showed the lowest toxicity of this series of compounds. The amide derivatives on the other hand were highly active in L 5222; all compounds effected cures in the dose range investigated.

摘要

研究了N-[N'-(2-氯乙基)-N'-亚硝基氨基甲酰基(CNC)]-氨基酸的7种酯衍生物和15种酰胺衍生物对移植性大鼠白血病L 5222的抗肿瘤活性。除CNC-L-异亮氨酸乙酯外，所有酯仅表现出中等抗肿瘤活性。CNC-L-异亮氨酸乙酯实现了部分治愈，且是该系列化合物中毒性最低的。另一方面，酰胺衍生物对L 5222具有高活性；在所研究的剂量范围内，所有化合物都实现了治愈。

相似文献

1
Antineoplastic activity of esters and amides of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-aminoacids.N-[N'-(2-氯乙基)-N'-亚硝基氨基甲酰基]-氨基酸酯和酰胺的抗肿瘤活性
J Cancer Res Clin Oncol. 1984;108(2):249-51. doi: 10.1007/BF00402478.
2
Androgen-linked alkylating agents: biological activity in methylnitrosourea-induced rat mammary carcinoma.雄激素相关烷化剂：在甲基亚硝基脲诱导的大鼠乳腺癌中的生物活性
J Cancer Res Clin Oncol. 1990;116(6):538-49. doi: 10.1007/BF01637072.
3
Cytostatic activity of steroid linked nitrosoureas.甾体连接亚硝基脲的细胞生长抑制活性。
J Cancer Res Clin Oncol. 1984;108(1):164-8. doi: 10.1007/BF00390991.
4
New derivatives of CNC-amino acids and -oligopeptides: experimental antitumor activity.CNC-氨基酸和-寡肽的新衍生物：实验性抗肿瘤活性。
J Cancer Res Clin Oncol. 1986;111(2):154-6. doi: 10.1007/BF00400755.
5
Synthesis and antineoplastic activity of CNC-cysteamine and related compounds.CNC-半胱胺及相关化合物的合成与抗肿瘤活性
J Cancer Res Clin Oncol. 1986;111(1):25-30. doi: 10.1007/BF00402771.
6
Activity of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-alanine and derivatives against transplantable adenocarcinomata of the mouse colon (MAC).N-[N'-(2-氯乙基)-N'-亚硝基氨基甲酰基]-丙氨酸及其衍生物对小鼠结肠可移植腺癌（MAC）的活性。
J Cancer Res Clin Oncol. 1986;112(1):47-9. doi: 10.1007/BF00394938.
7
Antineoplastic efficacy of melphalan and N-(2-chloroethyl)-N-nitrosocarbamoyl-omega-lysine, in combination with diazoxide or insulin in autochthonous mammary carcinoma of the Sprague-Dawley rat.美法仑和N-(2-氯乙基)-N-亚硝基氨基甲酰-ω-赖氨酸与二氮嗪或胰岛素联合应用于斯普拉格-道利大鼠自发性乳腺癌的抗肿瘤疗效。
J Cancer Res Clin Oncol. 1990;116(1):45-50. doi: 10.1007/BF01612639.
8
Examination of four newly synthesized 2-chloroethylnitrosoureas in comparison with BCNU, CCNU, MeCCNU, chlorozotocin and hydroxyethyl-CNU in preterminal rat leukemia L 5222.将四种新合成的2-氯乙基亚硝脲与卡莫司汀、洛莫司汀、司莫司汀、链脲佐菌素和羟乙基亚硝脲在晚期大鼠白血病L 5222中进行比较研究。
J Cancer Res Clin Oncol. 1979 Sep;95(1):43-9. doi: 10.1007/BF00411108.
9
Preclinical activity of 17 beta-[N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-L-alanyl]-5 alpha-dihydrotestosterone (E91) against tumour colony forming units and haematopoietic progenitor cells.
Eur J Cancer. 1999 Jun;35(6):1009-13. doi: 10.1016/s0959-8049(99)00034-9.
10
Examination of newly synthesized 2-chloroethylnitrosoureas in preterminal leukemia L 5222 and in two transplanted neurogenic tumors.
Arzneimittelforschung. 1982;32(5):481-4.

引用本文的文献

1
Activity of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-alanine and derivatives against transplantable adenocarcinomata of the mouse colon (MAC).N-[N'-(2-氯乙基)-N'-亚硝基氨基甲酰基]-丙氨酸及其衍生物对小鼠结肠可移植腺癌（MAC）的活性。
J Cancer Res Clin Oncol. 1986;112(1):47-9. doi: 10.1007/BF00394938.
2
Twenty-seventh annual general meeting of the British Association for Cancer Research (in conjunction with the inaugural meeting of the Association of Cancer Physicians). March 24-26, 1986, Bristol, UK. Abstracts.英国癌症研究协会第二十七届年会（与癌症医师协会成立大会联合举办）。1986年3月24日至26日，英国布里斯托尔。摘要
Br J Cancer. 1986 Jul;54(1):137-98. doi: 10.1038/bjc.1986.164.
3
New derivatives of CNC-amino acids and -oligopeptides: experimental antitumor activity.CNC-氨基酸和-寡肽的新衍生物：实验性抗肿瘤活性。
J Cancer Res Clin Oncol. 1986;111(2):154-6. doi: 10.1007/BF00400755.
4
Anticancer efficacy of 2-chloroethylnitrosocarbamoyl derivatives of L-alanine, glycine, their di- and tripeptide homologues and the respective amides in methylnitrosourea-induced rat mammary carcinoma.L-丙氨酸、甘氨酸的2-氯乙基亚硝基甲酰基衍生物、其二肽和三肽同系物以及相应酰胺在甲基亚硝基脲诱导的大鼠乳腺癌中的抗癌疗效
Br J Cancer. 1989 Mar;59(3):335-40. doi: 10.1038/bjc.1989.66.

本文引用的文献

1
Examination of newly synthesized 2-chloroethyl-nitrosoureas on rat leukemia L 5222.新型合成的2-氯乙基亚硝基脲对大鼠白血病L 5222的研究。
Oncology. 1981;38(1):39-42. doi: 10.1159/000225519.
2
Chemotherapeutic activity of 2-chloroethylnitrosocarbamoyl derivatives of amino acids in a transplanted rat leukemia (L 5222).氨基酸的2-氯乙基亚硝基氨基甲酰衍生物对移植大鼠白血病（L 5222）的化疗活性
Arzneimittelforschung. 1982;32(5):484-6.
3
(2-Chloroethyl)nitrosourea congeners of amino acid amides.氨基酸酰胺的（2-氯乙基）亚硝基脲类似物。
J Med Chem. 1982 Jul;25(7):829-32. doi: 10.1021/jm00349a012.
4
Chemotherapeutic activity of new 2-chloroethylnitrosoureas in rat L5222 leukemia: comparison of bifunctional and water-soluble derivatives with 1,3-bis(2-chloroethyl)-1-nitrosourea.
J Natl Cancer Inst. 1978 Feb;60(2):345-8. doi: 10.1093/jnci/60.2.345.
5
Examination of four newly synthesized 2-chloroethylnitrosoureas in comparison with BCNU, CCNU, MeCCNU, chlorozotocin and hydroxyethyl-CNU in preterminal rat leukemia L 5222.将四种新合成的2-氯乙基亚硝脲与卡莫司汀、洛莫司汀、司莫司汀、链脲佐菌素和羟乙基亚硝脲在晚期大鼠白血病L 5222中进行比较研究。
J Cancer Res Clin Oncol. 1979 Sep;95(1):43-9. doi: 10.1007/BF00411108.