Zimmermann I, de Almeida A A, Ulmer W T
Res Exp Med (Berl). 1980;177(2):101-9. doi: 10.1007/BF01851838.
Repeated ascaris extract (A.E.) exposure on dogs sensitized against this allergen at intervals of 90, 180, and 360 min is followed by different increases in the histamine concentration in the arterial plasma. At 90 min, a significantly smaller amount of histamine becomes measurable in the arterial plasma. Edyn increases unproportionally strong. One hundred eighty minutes after the first exposure A.E. inhalation is again followed by a clearly increased histamine concentration in the arterial plasma. Edyn still increases unproportionally strong. Three hundred sixty minutes after the first A.E. exposure another exposure revealed a stronger increase in the histamine concentration in the arterial plasma, the Edyn increase being smaller than at the first exposure. These results are of importance with regard to the sensitivity of the airways and the investigation of antiallergic and bronchospasmolytic drugs.
对已对该过敏原致敏的犬，每隔90、180和360分钟重复给予蛔虫提取物（A.E.），随后动脉血浆中的组胺浓度会有不同程度的升高。在90分钟时，动脉血浆中可检测到的组胺量显著减少。Edyn（可能是某种指标，未明确）不成比例地大幅增加。首次暴露A.E.吸入180分钟后，动脉血浆中的组胺浓度再次明显升高。Edyn仍然不成比例地大幅增加。首次暴露A.E.360分钟后再次暴露，动脉血浆中的组胺浓度升高更明显，而Edyn的增加幅度小于首次暴露时。这些结果对于气道敏感性以及抗过敏和支气管解痉药物的研究具有重要意义。
