Zimmermann I, Ulmer W T
Res Exp Med (Berl). 1980;177(3):193-200. doi: 10.1007/BF01851209.
The separate inhalation of A.E. aerosol in the upper and the peripheral parts of the airways in allergic dogs is followed by an increase of the histamine concentration in the arterial plasma. The correlation between the plasma histamine concentration and dynamic elastance and the correlation between dynamic elastance and arterial oxygen pressure is very similar following the challenge of the upper and the peripheral parts of the airways. The results argue for reflex bronchoconstriction also by challenge of the more peripheral airways. The results are in accord with the idea that the answer of Edyn depends on a product of local histamine concentration and the area in which the histamine is released. The number of sensory receptors per surface area which is suspected to be greater in the upper part of the airways may also be important.
在过敏性犬的气道上部和外周部分分别吸入A.E.气雾剂后，动脉血浆中的组胺浓度会升高。气道上部和外周部分受到刺激后，血浆组胺浓度与动态弹性之间的相关性以及动态弹性与动脉血氧压力之间的相关性非常相似。这些结果表明，更外周气道受到刺激也会引发反射性支气管收缩。这些结果与Edyn的反应取决于局部组胺浓度和组胺释放区域的乘积这一观点相符。气道上部每单位表面积的感觉受体数量可能更多，这一点也可能很重要。
