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[儿童慢性脑膜-皮肤-关节综合征]

[Chronic meningo-cutaneo-articular syndrome in children].

作者信息

Prieur A M, Griscelli C

出版信息

Rev Rhum Mal Osteoartic. 1980 Nov;47(11):645-9.

PMID:7444307
Abstract

The authors describe the case records of 3 unrelated children with a syndrome which started during the neonatal period and had a chronic course. This syndrome consisted of inflammatory joint disease involving all the large joints symmetrically, causing radiological lesions with a "bread crumb' appearance of the epiphyses and of the patella, ossified too early, with skin lesions, and neurological signs with persistence of chronic meningitis with neutrophil polymorphs and eosinophils. Infiltration by polymorphs of various organs e.g. skin, lymph nodes, synovial fluid and peripheral blood characterise this syndrome.

摘要

作者描述了3名无血缘关系儿童的病例记录,他们患有一种始于新生儿期且病程慢性的综合征。该综合征包括对称性累及所有大关节的炎性关节疾病,导致骨骺和髌骨出现“面包屑”样放射学病变,骨骺过早骨化,伴有皮肤病变,以及伴有中性多形核粒细胞和嗜酸性粒细胞的慢性脑膜炎持续存在的神经学体征。多形核粒细胞浸润各种器官,如皮肤、淋巴结、滑液和外周血,是该综合征的特征。

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