Wiener F, Babonits M, Spira J, Klein G, Potter M
Somatic Cell Genet. 1980 Nov;6(6):731-8. doi: 10.1007/BF01538972.
Seven IgA/lambda-producing murine plasmacytomas had the 12;15 translocation, previously found in IgA/kappa-producing plasmacytomas, and lacked the rcpT(6;15) translocation, also found in some kappa producers. The results suggest that the generation of the 12;15 translocation is an important, perhaps essential event during the genesis of plasmacytomas. The possibility that the distal region of chromosome 15 may contain a "supergene" area involved with the differentiation and/or normal responsiveness of various types of lymphoreticular cells, must be seriously considered on the basis of the present and previous evidence on plasmacytomas, as well as the extensive evidence now available on the role of chromosome 15-changes in the genesis of murine lymphomas. The involvement of chromosome 12 is of interest in view of the fact that it is known to carry the heavy-chain immunoglobulin determinants.
七个产生IgA/λ的小鼠浆细胞瘤发生了12;15易位，此前在产生IgA/κ的浆细胞瘤中发现过这种易位，并且缺乏rcpT(6;15)易位，后者在一些产生κ的浆细胞瘤中也有发现。结果表明，12;15易位的产生是浆细胞瘤发生过程中的一个重要事件，也许是必不可少的事件。根据目前和以往关于浆细胞瘤的证据，以及现在可获得的关于15号染色体变化在小鼠淋巴瘤发生中的作用的大量证据，必须认真考虑15号染色体远端区域可能包含一个与各种类型淋巴网状细胞的分化和/或正常反应性有关的“超基因”区域的可能性。鉴于已知12号染色体携带重链免疫球蛋白决定簇，其参与情况令人关注。
