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透闪石粉尘导致的胸膜钙化、胸膜间皮瘤和支气管癌。

Pleural calcification, pleural mesotheliomas, and bronchial cancers caused by tremolite dust.

作者信息

Yazicioglu S, Ilçayto R, Balci K, Sayli B S, Yorulmaz B

出版信息

Thorax. 1980 Aug;35(8):564-9. doi: 10.1136/thx.35.8.564.

DOI:10.1136/thx.35.8.564
PMID:7444823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC471336/
Abstract

Around the town of Cermik in south-east Turkey there are many deposits of asbestiform minerals, some of which are used to make whitewash or stucco. A sample of 7000 of the population revealed 461 (6.5%) with pleural thickening and calcification, of whom 103 (1.47% of the total) had evidence of interstitial pulmonary fibrosis. Forty-one patients with respiratory cancer were admitted to the Diyarbakir Chest Hospital from around Cermik and from a comparable area of equal population (but without asbestos deposits) in 1977-8. Of these 23 were mesotheliomas, 22 coming from around Cermik. In addition, 11 of the 18 primary bronchial cancers came from around Cermik. A similar excess of mesothelioma and bronchial cancer had been admitted from the Cermik area in previous years. The whitewash or stucco material has been shown to contain fibrous tremolite and non-fibrous antigorite/lizardite, chlorite, and talc. A lung biopsy of a patient from Cermik contained large numbers of tremolite fibres, both free and forming asbestos bodies. There were only occasional chrysotile fibres.

摘要

在土耳其东南部的塞尔米克镇周围,有许多石棉状矿物矿床,其中一些被用于制作石灰浆或灰泥。对7000名居民的抽样调查显示,有461人(6.5%)出现胸膜增厚和钙化,其中103人(占总人数的1.47%)有间质性肺纤维化的迹象。1977年至198年期间,有41名来自塞尔米克镇周边以及人口相当的类似地区(但没有石棉矿床)的呼吸道癌症患者被收治进迪亚巴克尔胸科医院。其中23例为间皮瘤,22例来自塞尔米克镇周边。此外,18例原发性支气管癌中有11例来自塞尔米克镇周边。往年从塞尔米克地区收治的间皮瘤和支气管癌患者也有类似的超额情况。已证明石灰浆或灰泥材料中含有纤维状透闪石以及非纤维状叶蛇纹石/纤蛇纹石、绿泥石和滑石。一名来自塞尔米克镇的患者的肺活检显示含有大量游离的和形成石棉小体的透闪石纤维。只有偶尔的温石棉纤维。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/471336/86abf74daf04/thorax00176-0008-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/471336/ba491e0ec5bd/thorax00176-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/471336/b9a909f0930a/thorax00176-0006-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/471336/cc79af9cd746/thorax00176-0007-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/471336/e90be79c27b7/thorax00176-0007-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/471336/86abf74daf04/thorax00176-0008-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/471336/ba491e0ec5bd/thorax00176-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/471336/b9a909f0930a/thorax00176-0006-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/471336/cc79af9cd746/thorax00176-0007-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/471336/e90be79c27b7/thorax00176-0007-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/471336/86abf74daf04/thorax00176-0008-a.jpg

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