The persistence of the effect of methylglucamine orotate on the retention of a learned behavior in the rat.

The effects of methylglucamine orotate (MGO) on the retention of a brightness discrimination in rats was investigated after different intervals between treatment and acquisition, 225 mg MGO/kg were injected intraperitoneally each day over a period of 10 days. Control animals received a NaCl-solution. After drug-free intervals of 5 days or 12 days respectively, MGO-treated rats showed significantly better retention of the learned reaction than controls, whereas their training performance was not influenced. Possible interpretations of the long-lasting persistence of the orotate effect are discussed.