Rüthrich H L, Wetzel W, Matthies H
Acta Biol Med Ger. 1980;39(4):415-8.
The effects of methylglucamine orotate (MGO) on the retention of a brightness discrimination in rats was investigated after different intervals between treatment and acquisition, 225 mg MGO/kg were injected intraperitoneally each day over a period of 10 days. Control animals received a NaCl-solution. After drug-free intervals of 5 days or 12 days respectively, MGO-treated rats showed significantly better retention of the learned reaction than controls, whereas their training performance was not influenced. Possible interpretations of the long-lasting persistence of the orotate effect are discussed.
研究了乳清酸葡甲胺（MGO）对大鼠亮度辨别记忆保持的影响，在治疗与习得之间设置了不同的间隔时间，每天腹腔注射225mg MGO/kg，持续10天。对照动物接受氯化钠溶液。在分别经过5天或12天的无药间隔期后，接受MGO治疗的大鼠在习得反应的记忆保持方面显著优于对照组，而它们的训练表现未受影响。文中讨论了乳清酸效应长期持续存在的可能解释。
