对另一只大鼠疼痛刺激的回避反应：乳清酸甲基葡胺的作用。
Avoidance reaction of painful stimulation of another rat: effect of methylglucamine orotate.
作者信息
Wetzel W, Simonov P V
出版信息
Pharmacol Biochem Behav. 1978 Oct;9(4):401-4. doi: 10.1016/0091-3057(78)90030-8.
An avoidance reaction to painful stimulation of another animal was developed in rats. Two hundred twenty-five mg/kg methylglucamine orotate was injected intraperitoneally each day, 1 hr before the training session. The orotate treated rats showed an accelerated development of the avoidance reaction during 5 days of training. Depending on the experimental conditions, extinction of the reaction was delayed in orotate treated rats, compared to saline controls. The results from these experiments, using neither footshock punishment nor food reward as reinforcement, give further evidence for the improvement of long term memory by orotic acid.
在大鼠中建立了对另一只动物疼痛刺激的回避反应。每天在训练前1小时腹腔注射225mg/kg的乳清酸甲基葡糖胺。在5天的训练过程中，经乳清酸处理的大鼠回避反应的发展加速。根据实验条件，与生理盐水对照组相比，经乳清酸处理的大鼠反应的消退延迟。这些实验结果既未使用电击惩罚也未使用食物奖励作为强化手段，进一步证明了乳清酸对长期记忆的改善作用。
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