Oldfors A, Ullman M
Acta Neuropathol. 1980;51(3):215-21. doi: 10.1007/BF00687388.
Motor nerve conduction velocity (MCV) and nerve fibre calibre spectra of peripheral nerves were determined at different ages, during development in normal and protein-deprived rats. The protein deprivation was achieved by feeding female rats a protein deficient diet. Compared to control rats which were given a balanced diet, given ad lib from 2 weeks before conception and onwards. After weaning, the offspring were fed the same protein-deficient diet, the protein-deprived rats showed considerably reduced body weights but moderately reduced values of albumin and total protein in serum at 6 and 15 weeks of age. Although essentially the same, the mean nerve fibre diameter of the studied dorsal tail nerve was slightly larger in the protein-deprived rats at 6 weeks of age than in controls, while the inverse relationship was found at 15 weeks of age. The increase of MCV in normal and protein-deprived rats followed essentially the same curve during the period from 5-30 weeks of age. The results indicate that the MCV and nerve fibre diameter during development are correlated to chronological age and not to body size, although protein deprivation may, to a minor extent, influence nerve fibre calibre growth.
在正常和蛋白质缺乏的大鼠发育过程中的不同年龄段，测定了外周神经的运动神经传导速度（MCV）和神经纤维直径谱。通过给雌性大鼠喂食蛋白质缺乏的饮食来实现蛋白质缺乏。与从受孕前2周开始随意喂食均衡饮食的对照大鼠相比。断奶后，后代喂食相同的蛋白质缺乏饮食，蛋白质缺乏的大鼠在6周和15周龄时体重显著降低，但血清白蛋白和总蛋白值适度降低。尽管基本相同，但在6周龄时，蛋白质缺乏大鼠的研究背尾神经平均神经纤维直径略大于对照组，而在15周龄时则发现相反的关系。在5至30周龄期间，正常和蛋白质缺乏大鼠的MCV增加基本遵循相同的曲线。结果表明，发育过程中的MCV和神经纤维直径与实际年龄相关，而与体型无关，尽管蛋白质缺乏可能在较小程度上影响神经纤维直径的生长。
