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耵聍的杀菌活性。

Bactericidal activity of cerumen.

作者信息

Chai T J, Chai T C

出版信息

Antimicrob Agents Chemother. 1980 Oct;18(4):638-41. doi: 10.1128/AAC.18.4.638.

DOI:10.1128/AAC.18.4.638
PMID:7447422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284062/
Abstract

Freshly collected cerumen (dry form) suspended at a concentration of 3% in glycerol-sodium bicarbonate buffer showed bactericidal activity against some strains of bacteria tested. This suspension reduced the viability of Haemophilus influenzae, Escherichia coli K-12, and Serratia marcescens by more than 99%, whereas the viability of two Pseudomonas aeruginosa isolates, E. coli K-1, Streptococcus, and two Staphylococcus aureus isolates of human origin was reduced by 30 to 80%. The results support the hypothesis that cerumen functions to kill certain foreign organisms which enter the ear canal.

摘要

新鲜采集的耵聍(干型)以3%的浓度悬浮于甘油 - 碳酸氢钠缓冲液中,对所测试的一些细菌菌株显示出杀菌活性。该悬浮液使流感嗜血杆菌、大肠杆菌K - 12和粘质沙雷氏菌的活力降低了99%以上,而两种铜绿假单胞菌分离株、大肠杆菌K - 1、链球菌以及两种人源金黄色葡萄球菌分离株的活力降低了30%至80%。这些结果支持了耵聍具有杀死进入耳道的某些外来生物体这一假说。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e8b/284062/703353832bb4/aac00390-0154-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e8b/284062/703353832bb4/aac00390-0154-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e8b/284062/703353832bb4/aac00390-0154-a.jpg

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本文引用的文献

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Otitis externa; bacteriological and mycological studies.外耳道炎;细菌学和真菌学研究
Ann Otol Rhinol Laryngol. 1952 Jun;61(2):317-30. doi: 10.1177/000348945206100201.
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Studies on the growth of bacteria in the human ear canal.关于人耳道内细菌生长的研究。
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The comparison of lipids between dry and wet types of cerumen.干性与湿性耵聍的脂质比较。
内窥镜掏耳勺:一种新兴但被忽视的医疗器械。
Front Med (Lausanne). 2022 Nov 15;9:977554. doi: 10.3389/fmed.2022.977554. eCollection 2022.
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Identification of Altered miRNAs in Cerumen of Dogs Affected by Otitis Externa.鉴定受外耳炎影响的犬耳垢中改变的 miRNA。
Front Immunol. 2020 May 29;11:914. doi: 10.3389/fimmu.2020.00914. eCollection 2020.
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Earwax: A potentially useful medium to identify inborn errors of metabolism?耳垢:一种用于识别先天性代谢缺陷的潜在有用介质?
JIMD Rep. 2020 Feb 14;52(1):72-78. doi: 10.1002/jmd2.12102. eCollection 2020 Mar.
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Insights into cerumen and application in diagnostics: past, present and future prospective.耳垢的研究进展及其在诊断中的应用:过去、现在和未来展望。
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Identification of volatile organic compounds in human cerumen.人耳垢中挥发性有机化合物的鉴定
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 15;953-954:48-52. doi: 10.1016/j.jchromb.2014.01.043. Epub 2014 Feb 5.
8
Lipolytic, proteolytic, and cholesterol-degrading bacteria from the human cerumen.人耳耵聍中的脂肪分解菌、蛋白分解菌和胆固醇降解菌。
Curr Microbiol. 2012 Jun;64(6):588-91. doi: 10.1007/s00284-012-0113-8. Epub 2012 Mar 29.
9
Non-polar lipid components of human cerumen.人耳垢的非极性脂质成分。
Lipids. 2011 Aug;46(8):781-8. doi: 10.1007/s11745-011-3564-y. Epub 2011 May 6.
10
Human antimicrobial proteins in ear wax.人耳垢中的抗菌蛋白。
Eur J Clin Microbiol Infect Dis. 2011 Aug;30(8):997-1004. doi: 10.1007/s10096-011-1185-2. Epub 2011 Feb 6.
Tohoku J Exp Med. 1967 Mar;91(3):227-37. doi: 10.1620/tjem.91.227.
4
Cerumen and its micro-chemical analysis.耵聍及其微量化学分析。
J Laryngol Otol. 1966 Sep;80(9):933-8. doi: 10.1017/s0022215100066196.
5
Ear wax and host defense.耳垢与宿主防御。
N Engl J Med. 1971 May 13;284(19):1099-100. doi: 10.1056/NEJM197105132841913.
6
Evidence for a genetic cline in earwax types in the Middle East and Southeast Asia.中东和东南亚耳垢类型存在基因渐变的证据。
Am J Phys Anthropol. 1971 Jul;35(1):141-4. doi: 10.1002/ajpa.1330350117.
7
Immunity to Hemophilus influenzae type b. I. The isolation, and some physicochemical, serologic and biologic properties of the capsular polysaccharide of Hemophilus influenzae type b.b型流感嗜血杆菌的免疫性。I. b型流感嗜血杆菌荚膜多糖的分离及其一些物理化学、血清学和生物学特性
J Immunol. 1971 Oct;107(4):1071-80.
8
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