Lecaillon J B, Hirtz J L, Schoeller J P, Humbert G, Vischer W
Antimicrob Agents Chemother. 1980 Nov;18(5):656-60. doi: 10.1128/AAC.18.5.656.
The pharmacokinetic parameters of cefroxadin and cephalexin were compared after simultaneous oral administration of the two cephalosporins to 21 subjects. The influence of the dose, the formulation, and food intake on these parameters was investigated. Both drugs were equally well absorbed from all of the tested formulations; identical percentages of the dose were recovered in the urine in all cases. The elimination half-life of cefroxadin and, consequently, the area under the plasma concentration-time curve were about 10% less than those of cephalexin. Plasma concentrations and cumulative excretion curves of the two drugs were almost superimposable. Food intake had the same effect on both drugs; absorption was slowed, but the amounts absorbed were almost the same as those in fasted subjects.
将两种头孢菌素同时口服给予21名受试者后，比较了头孢沙定和头孢氨苄的药代动力学参数。研究了剂量、剂型和食物摄入对这些参数的影响。两种药物从所有测试剂型中的吸收情况相同；在所有情况下，尿液中回收的剂量百分比相同。头孢沙定的消除半衰期以及血浆浓度-时间曲线下面积比头孢氨苄约低10%。两种药物的血浆浓度和累积排泄曲线几乎重叠。食物摄入对两种药物产生相同的影响；吸收减慢，但吸收量与空腹受试者几乎相同。
