锌对溶血的抑制作用及其被L-组氨酸逆转的情况。
Inhibition of hemolysis by zinc and its reversal by L-histidine.
作者信息
Avigad L S, Bernheimer A W
出版信息
Infect Immun. 1978 Mar;19(3):1101-3. doi: 10.1128/iai.19.3.1101-1103.1978.
Abstract
Hemolysis induced by staphylococcal alpha-toxin, staphylococcal beta-toxin, streptolysin O, and streptolysin S was inhibited by zinc ions by virtue of inhibition of an early step in the events leading to lysis, presumably by preventing the lysins from attaching to the plasma membrane. In contrast, in hemolysis induced by Clostridium perfringens alpha-toxin and by perfringolysin O, a later step was inhibited by zinc. In hemolysis caused by saponin, lysolecithin, and Triton X-100, hemoglobin was precipitated by zinc ions as it was released from the erythrocyte. Inhibition by zinc was abolished by several amino acids of which L-histidine was the most effective.
摘要
葡萄球菌α毒素、葡萄球菌β毒素、链球菌溶血素O和链球菌溶血素S所诱导的溶血作用可被锌离子抑制，这是由于锌离子抑制了导致细胞溶解的早期步骤，推测是通过阻止溶血素附着于质膜来实现的。相比之下，在产气荚膜梭菌α毒素和产气荚膜梭菌溶血素O所诱导的溶血作用中，锌离子抑制的是后期步骤。在皂苷、溶血卵磷脂和曲拉通X-100所引起的溶血作用中，当血红蛋白从红细胞中释放出来时，会被锌离子沉淀。锌离子的抑制作用可被几种氨基酸消除，其中L-组氨酸最为有效。
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