Gonzalez Buitrago J M, Miralles J M, Muńoz M H, Meza S, Alonso M T, Garcia Diez L C
Arch Androl. 1980 Dec;5(4):355-60. doi: 10.3109/01485018008987006.
Creatine kinase activity was measured in the seminal fluid of 70 males undergoing fertility studies. The average value obtained at 30 degrees C was 333 +/- 197 IU/l (average +/- SD). There was no evidence of a significant correlation between creatine kinase enzymatic activity and density, active lineal motility, or number of normal motile spermatozoa; nor was there any correlation seen between creatine kinase activity and concentration of citric acid, (indicator of prostatic function) or fructose, (indicator of seminal vesicle function). Nonetheless, in two cases of excretory azoospermia, very high values of creatine kinase (2510 and 1280 IU/l) and citric acid levels (4000 and 3000 mg/dl) were observed. These would indicate that the origin of creatine kinase is fundamentally prostatic, in contradiction to previous studies by other authors. In this sense, creatine kinase would be a parameter of prostatic function in studies of male fertility. In two cases of secretory azoospermia due to cryptorchidism and in several very severe oligoasthenozoospermias, low creatine kinase levels were seen, while fructose and citric acid levels were normal. This would give relative value to creatine kinase as an indicator of spermatogenesis.
对70名接受生育力研究的男性精液中的肌酸激酶活性进行了测定。在30摄氏度下获得的平均值为333±197 IU/l（平均值±标准差）。没有证据表明肌酸激酶酶活性与精子密度、直线活动率或正常活动精子数量之间存在显著相关性；肌酸激酶活性与柠檬酸（前列腺功能指标）或果糖（精囊功能指标）浓度之间也没有相关性。然而，在两例排泄性无精子症患者中，观察到肌酸激酶值非常高（分别为2510和1280 IU/l）以及柠檬酸水平很高（分别为4000和3000 mg/dl）。这表明肌酸激酶的来源基本上是前列腺，这与其他作者之前的研究结果相矛盾。从这个意义上说，在男性生育力研究中，肌酸激酶将是前列腺功能的一个参数。在两例因隐睾症导致的分泌性无精子症病例以及几例非常严重的少弱精子症病例中，肌酸激酶水平较低，而果糖和柠檬酸水平正常。这将赋予肌酸激酶作为精子发生指标的相对价值。
