Carrascosa A, Prevot C, Evain D, Czernichow P, Rappaport R
Arch Fr Pediatr. 1980 Oct;37(8):515-9.
Somatomedin activity, as estimated by the porcine bioassay and GH response to stimulation were compared in prepubertal children with severe growth retardation and lack of evidence of pituitary dysfunction. Somatomedin activity was strongly correlated with growth rate. A group of patients had a low somatomedin activity in contrast with normal GH responsiveness. This appears to be a rather frequent situation and deserves further evaluation of the somatomedin system and a more critical approach of GH secretion.
通过猪生物测定法估算的生长调节素活性，以及生长激素对刺激的反应，在青春期前患有严重生长迟缓且无垂体功能障碍证据的儿童中进行了比较。生长调节素活性与生长速率密切相关。一组患者生长调节素活性较低，但其生长激素反应正常。这似乎是一种相当常见的情况，值得对生长调节素系统进行进一步评估，并对生长激素分泌采取更严格的研究方法。
