盐酸金刚乙胺可阻断流感病毒脱壳的第二步。
Rimantadine hydrochloride blocks the second step of influenza virus uncoating.
作者信息
Bukrinskaya A G, Vorkunova N K, Narmanbetova R A
出版信息
Arch Virol. 1980;66(3):275-82. doi: 10.1007/BF01314742.
PMID:7447705
Abstract
Two steps of influenza virus A/WSN uncoating in MDCK cells are described. The products of the first step are cores which accumulate in the nuclear-associated cytoplasm. The products of the second step are ribonucleoproteins which penetrate the nuclei. Rimantadine blocks the second step without interfering with the first one.
摘要
本文描述了甲型流感病毒A/WSN在MDCK细胞中脱壳的两个步骤。第一步的产物是核心颗粒，它们聚集在与细胞核相关的细胞质中。第二步的产物是核糖核蛋白，它们穿透细胞核。金刚烷胺可阻断第二步，而不干扰第一步。
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