盐酸金刚烷胺对流感病毒脱壳的抑制作用。
Inhibition of influenza virus uncoating by rimantadine hydrochloride.
作者信息
Koff W C, Knight V
出版信息
J Virol. 1979 Jul;31(1):261-3. doi: 10.1128/JVI.31.1.261-263.1979.
Abstract
In freeze-thaw lysates of MDCK cells infected with 32P-labeled influenza virus A/WSN in the presence of added RNase, acid-precipitable radioactivity diminished to about 50% of initial values within 90 min after a 1-h virus adsorption period. A similar preparation containing rimantadine at a concentration of 50 micrograms/ml exhibited only a 10% reduction in acid-precipitable radioactivity. These findings suggest that rimantadine interferes with uncoating of influenza virus in infected cells.
摘要
在添加了核糖核酸酶的情况下，用32P标记的甲型流感病毒A/WSN感染的MDCK细胞冻融裂解物中，经过1小时的病毒吸附期后，酸可沉淀放射性在90分钟内降至初始值的约50%。含有浓度为50微克/毫升金刚乙胺的类似制剂，其酸可沉淀放射性仅降低了10%。这些发现表明金刚乙胺会干扰感染细胞中流感病毒的脱壳过程。
相似文献
1
Inhibition of influenza virus uncoating by rimantadine hydrochloride.盐酸金刚烷胺对流感病毒脱壳的抑制作用。
J Virol. 1979 Jul;31(1):261-3. doi: 10.1128/JVI.31.1.261-263.1979.
2
Uncoating of a rimantadine-resistant variant of influenza virus in the presence of rimantadine.在金刚烷胺存在的情况下，抗金刚烷胺流感病毒变异株的脱壳过程
J Gen Virol. 1982 May;60(Pt 1):61-6. doi: 10.1099/0022-1317-60-1-61.
3
Rimantadine hydrochloride blocks the second step of influenza virus uncoating.盐酸金刚乙胺可阻断流感病毒脱壳的第二步。
Arch Virol. 1980;66(3):275-82. doi: 10.1007/BF01314742.
4
Influenza virus uncoating in infected cells and effect of rimantadine.流感病毒在受感染细胞中的脱壳及金刚烷胺的作用。
J Gen Virol. 1982 May;60(Pt 1):49-59. doi: 10.1099/0022-1317-60-1-49.
5
6
7
8
[Mechanism of action of remantadine hydrochloride on Sindbis virus reproduction: inhibition of virus penetration into the cell].
Vopr Med Khim. 1986 Nov-Dec;32(6):118-20.
9
Suppression of dengue virus replication in vitro by rimantadine hydrochloride.
Am J Trop Med Hyg. 1981 Jan;30(1):184-9. doi: 10.4269/ajtmh.1981.30.184.
10
Demonstration of influenza virus reproduction stages sensitive to remantadine.
Virologie. 1980 Jan-Mar;31(1):13-9.
引用本文的文献
1
Molecular docking and simulation studies of Chloroquine, Rimantadine and CAP-1 as potential repurposed antivirals for decapod iridescent virus 1 (DIV1).氯喹、金刚烷胺和CAP-1作为对十足目虹彩病毒1（DIV1）潜在的重新利用抗病毒药物的分子对接和模拟研究。
Fish Shellfish Immunol Rep. 2023 Oct 8;5:100120. doi: 10.1016/j.fsirep.2023.100120. eCollection 2023 Dec 15.
2
The effect of random virus failure following cell entry on infection outcome and the success of antiviral therapy.随机病毒在进入细胞后发生故障对感染结果和抗病毒治疗的成功的影响。
Sci Rep. 2023 Oct 11;13(1):17243. doi: 10.1038/s41598-023-44180-w.
3
Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection.单细胞分析与随机建模揭示甲型流感病毒感染中细胞间存在巨大变异性。
Nat Commun. 2015 Nov 20;6:8938. doi: 10.1038/ncomms9938.
4
Cell penetrable human scFv specific to middle domain of matrix protein-1 protects mice from lethal influenza.针对基质蛋白-1中间结构域的可穿透细胞的人单链抗体片段可保护小鼠免受致命性流感病毒感染。
Viruses. 2015 Jan 14;7(1):154-79. doi: 10.3390/v7010154.
5
Transport of the influenza virus genome from nucleus to nucleus.流感病毒基因组从细胞核到细胞核的运输。
Viruses. 2013 Oct 2;5(10):2424-46. doi: 10.3390/v5102424.
6
Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesis.建立流感病毒复制的细胞内动力学模型以理解病毒 RNA 合成的控制。
J Virol. 2012 Aug;86(15):7806-17. doi: 10.1128/JVI.00080-12. Epub 2012 May 16.
7
Receptor-mediated Moloney murine leukemia virus entry can occur independently of the clathrin-coated-pit-mediated endocytic pathway.受体介导的莫洛尼鼠白血病病毒进入过程可独立于网格蛋白包被小窝介导的内吞途径发生。
J Virol. 1999 Jul;73(7):5994-6005. doi: 10.1128/JVI.73.7.5994-6005.1999.
8
Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins.M1蛋白和低pH值对流感病毒核糖核蛋白核转运的影响。
J Virol. 1996 Dec;70(12):8391-401. doi: 10.1128/JVI.70.12.8391-8401.1996.
9
Regulatory effects of matrix protein variations on influenza virus growth.
Arch Virol. 1993;133(3-4):283-94. doi: 10.1007/BF01313769.
10
Rimantadine hydrochloride blocks the second step of influenza virus uncoating.盐酸金刚乙胺可阻断流感病毒脱壳的第二步。
Arch Virol. 1980;66(3):275-82. doi: 10.1007/BF01314742.
本文引用的文献
1
ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE (AMANTADINE).1-金刚烷胺（金刚烷胺）的抗病毒活性。
Science. 1964 May 15;144(3620):862-3. doi: 10.1126/science.144.3620.862.
2
THE INTRACELLULAR UNCOATING OF POXVIRUS DNA. I. THE FATE OF RADIOACTIVELY-LABELED RABBITPOX VIRUS.痘病毒DNA的细胞内脱壳。I. 放射性标记兔痘病毒的命运
J Mol Biol. 1964 Feb;8:263-76. doi: 10.1016/s0022-2836(64)80136-4.
3
Distinct subunits of the ribonucleoprotein of influenza virus.流感病毒核糖核蛋白的不同亚基。
J Mol Biol. 1969 Jun 28;42(3):485-99. doi: 10.1016/0022-2836(69)90237-x.
4
Inhibition of uncoating of fowl plague virus by l-adamantanamine hydrochloride.盐酸L-金刚烷胺对鸡瘟病毒脱壳的抑制作用。
Virology. 1969 Apr;37(4):632-41. doi: 10.1016/0042-6822(69)90281-5.
5
Chloroquine: mode of action.氯喹：作用方式
Science. 1966 Jan 21;151(3708):347-9. doi: 10.1126/science.151.3708.347.
6
Therapeutic efficacy of amantadine HCl and rimantadine HCl in naturally occurring influenza A2 respiratory illness in man.盐酸金刚烷胺和盐酸金刚乙胺对人类自然发生的甲型流感2型呼吸道疾病的治疗效果。
N Engl J Med. 1969 Sep 11;281(11):579-84. doi: 10.1056/NEJM196909112811102.
7
Treatment of influenza. The therapeutic efficacy of rimantadine HC1 in a naturally occurring influenza A2 outbreak.流感的治疗。盐酸金刚乙胺在自然发生的甲型流感2型疫情中的治疗效果。
Am J Med Sci. 1969 May;257(5):328-35. doi: 10.1097/00000441-196905000-00005.
8
Stability and precursor relationships of virus RNA.病毒RNA的稳定性及前体关系
J Gen Virol. 1972 Nov;17(2):213-9. doi: 10.1099/0022-1317-17-2-213.
9
Alpha-methyl-1-adamantane-methylamine hydrochloride: inhibition of Rous and Esh sarcoma viruses in cell culture.
Proc Soc Exp Biol Med. 1969 Jul;131(3):1025-7. doi: 10.3181/00379727-131-34032.
10
Isolation and properties of the helical nucleocapsid of the parainfluenza virus SV5.副流感病毒SV5螺旋核衣壳的分离及特性
Proc Natl Acad Sci U S A. 1967 Apr;57(4):949-56. doi: 10.1073/pnas.57.4.949.
Zotero 插件