沙丁胺醇通过压力定量气雾剂和湿式雾化器治疗急性哮喘的疗效比较
Comparative efficacy of salbutamol by pressurized aerosol and wet nebulizer in acute asthma.
作者信息
Tarala R A, Madsen B W, Paterson J W
出版信息
Br J Clin Pharmacol. 1980 Oct;10(4):393-7. doi: 10.1111/j.1365-2125.1980.tb01776.x.
Abstract
1 Cumulative dose-response curves (FEV1) to pressurized aerosol salbutamol were established in 17 patients admitted to hospital with acute severe asthma. After the maximal pressurized aerosol effect had been achieved, a further dose (5 mg) of salbutamol was given by wet nebulizer and any further increment recorded. 2 Baseline FEV1 was 1.16 +/- 0.55 (mean +/- s.d.), an average of 36% of predicted, and the maximal aerosol induced change in FEV1 was 0.435 +/- 0.330 1 (t = 5.72, P < 0.01). There was an additional, small increment in FEV1 after nebulizer of 0.043 +/- 0.085 1 (t = 2.26, P < 0.05). 3 Detailed analysis of the data according to a theoretical dose-response relationship showed that the nebulizer-aerosol increment was unrelated to asthma severity.
摘要
- 对17例因急性重症哮喘入院的患者建立了加压气雾剂沙丁胺醇的累积剂量 - 反应曲线（FEV1）。在达到最大加压气雾剂效果后，通过湿式雾化器给予另外一剂（5毫克）沙丁胺醇，并记录任何进一步的增加量。2. 基线FEV1为1.16±0.55（平均值±标准差），平均为预测值的36%，气雾剂诱导的FEV1最大变化为0.435±0.330升（t = 5.72，P < 0.01）。雾化器给药后FEV1还有额外的小幅度增加，为0.043±0.085升（t = 2.26，P < 0.05）。3. 根据理论剂量 - 反应关系对数据进行的详细分析表明，雾化器 - 气雾剂增加量与哮喘严重程度无关。
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