Wrońska-Nofer T, Szendzikowski S, Obrebska-Parke M
Br J Ind Med. 1980 Nov;37(4):387-93. doi: 10.1136/oem.37.4.387.
Rats fed on atherogenic diets containing 2% cholesterol and 0.5% cholic acid with or without 0.15% thiouracil were exposed to carbon disulphide (CS2) vapours (1 mg/l of air), five hours a day, six days a week for 6-10 months. Serum and aorta lipid contents were determined, and the extent of atherosclerotic changes was investigated. The following effects of chronic exposure to CS2 were found: (1) slower gain in body weight when rats were fed on atherogenic diet; (2) greater increase in serum cholesterol content (after thiouracil supplemented diet); (3) moderate increase in total cholesterol content in the aorta wall with a significantly increased esterified cholesterol fraction but none in phospholipid level in this tissue; and (4) more advanced lipid infiltrates of coronary arteries and endocardium, the latter predominantly in the aortic valves. These results together with data from previous studies indicate that metabolism of arterial lipids participates in the process of artheroma formation after chronic exposure to CS2 vapours.
给喂食含2%胆固醇和0.5%胆酸的致动脉粥样化饮食的大鼠，添加或不添加0.15%硫脲，每天5小时、每周6天暴露于二硫化碳（CS2）蒸气（1毫克/升空气）中，持续6至10个月。测定血清和主动脉脂质含量，并研究动脉粥样硬化变化程度。发现长期暴露于CS2有以下影响：（1）喂食致动脉粥样化饮食时体重增加较慢；（2）血清胆固醇含量增加更多（补充硫脲饮食后）；（3）主动脉壁总胆固醇含量适度增加，酯化胆固醇部分显著增加，但该组织中磷脂水平无变化；（4）冠状动脉和心内膜脂质浸润更严重，后者主要在主动脉瓣。这些结果与先前研究的数据表明，长期暴露于CS2蒸气后，动脉脂质代谢参与了动脉粥样硬化形成过程。
