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白内障及白内障手术后针对晶状体抗原的抗体。

Antibodies to lens antigens in cataract and after cataract surgery.

作者信息

Nissen S H, Andersen P, Andersen H M

出版信息

Br J Ophthalmol. 1981 Jan;65(1):63-6. doi: 10.1136/bjo.65.1.63.

DOI:10.1136/bjo.65.1.63
PMID:7448158
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1039415/
Abstract

By means of an enzyme-linked immunosorbent assay (ELISA) antibodies to whole lens homogenate were found in 50.0% of 38 patients with senile cataract and in 57.3% of 75 controls. The antibody titres were in the range of 10-160 in both groups. IgG antibodies occurred in 44.7% of patients and in 45.3% of controls, whereas IgM antibodies were found in 21.1% of the patients and in 40.0% of the controls (not significant). Postoperative uveitis occurred in 5 (31.6%) of 19 patients, who had antibodies in serum prior to the operation and in only 2 (10.5%) of 19 antibody-negative patients (P = 0.10).

摘要

通过酶联免疫吸附测定(ELISA)法发现,38例老年性白内障患者中有50.0%、75例对照者中有57.3%存在针对晶状体全匀浆的抗体。两组的抗体滴度范围均为10 - 160。44.7%的患者和45.3%的对照者出现IgG抗体,而21.1%的患者和40.0%的对照者发现有IgM抗体(无显著差异)。19例术前血清中有抗体的患者术后发生葡萄膜炎的有5例(31.6%),而19例抗体阴性患者中仅2例(10.5%)发生葡萄膜炎(P = 0.10)。

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1
Antibodies to lens antigens in cataract and after cataract surgery.白内障及白内障手术后针对晶状体抗原的抗体。
Br J Ophthalmol. 1981 Jan;65(1):63-6. doi: 10.1136/bjo.65.1.63.
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引用本文的文献

1
Immunochemical detection of glycated lens crystallins and their circulating autoantibodies in human serum during aging.衰老过程中人体血清中糖化晶状体蛋白及其循环自身抗体的免疫化学检测。
Mol Vis. 2008;14:2056-66. Epub 2008 Nov 17.
2
High incidence of antibodies to lens proteins in sera from patients with uveitis.葡萄膜炎患者血清中晶状体蛋白抗体的高发生率。
Graefes Arch Clin Exp Ophthalmol. 2007 May;245(5):683-8. doi: 10.1007/s00417-006-0407-2. Epub 2006 Sep 19.
3
Characterization of anti-crystallin autoantibodies in patients with cataract.白内障患者抗晶状体蛋白自身抗体的特征分析
Mol Biol Rep. 1993 Feb;17(2):93-9. doi: 10.1007/BF00996216.
4
Phacolytic glaucoma and lens-induced uveitis.
Int Ophthalmol. 1993 Oct;17(5):289-93. doi: 10.1007/BF01007798.
5
Antilens antibodies in cataract and inflammatory eye disease: an evaluation of a new technique.白内障和炎症性眼病中的抗晶状体抗体:一种新技术的评估
Int Ophthalmol. 1990 Mar;14(2):97-100. doi: 10.1007/BF00154208.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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AUTO-IMMUNITY IN UVEITIS.葡萄膜炎中的自身免疫
Br J Ophthalmol. 1964 Feb;48(2):61-9. doi: 10.1136/bjo.48.2.61.
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ANTI-LENS ANTIBODY IN HUMAN SERA.人血清中的抗晶状体抗体。
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Anti-uveal and anti-lens antibodies in uveitis and their significance.葡萄膜炎中的抗葡萄膜和抗晶状体抗体及其意义。
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Lens-induced uveitis.晶状体诱导性葡萄膜炎
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Incidence and titers of antinuclear, antismooth muscle, and other autoantibodies in blood donors.献血者血液中抗核抗体、抗平滑肌抗体及其他自身抗体的发生率和滴度
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10
Immunopathology of the lens. III. Humoral and cellular immune responses to autologous lens antigens and their roles in ocular inflammation.晶状体的免疫病理学。III. 对自身晶状体抗原的体液免疫和细胞免疫反应及其在眼部炎症中的作用。
Br J Ophthalmol. 1977 Jun;61(6):371-9. doi: 10.1136/bjo.61.6.371.