[Relationship between myocardial contractile activity and the concentration of endogenous prostaglandins in the heart].

The time-dependent positive correlation between myocardial contractility and myocardial level of prostaglandins (PG) was found after acute pressure overload. The PG level and contractility were observed to correlate well just after aortal stenosis. This correlation became less marked after more prolonged periods of adaptation to overload. A suggestion is made that a rapid increase in the PG content is required for triggering the biochemical mechanism of heart adaptation after the stressful factor.